Näytä suppeat kuvailutiedot

dc.contributor.authorCheng, Runtan
dc.contributor.authorWang, Lu
dc.contributor.authorLe, Shenglong
dc.contributor.authorYang, Yifan
dc.contributor.authorZhao, Can
dc.contributor.authorZhang, Xiangqi
dc.contributor.authorYang, Xin
dc.contributor.authorXu, Ting
dc.contributor.authorXu, Leiting
dc.contributor.authorWiklund, Petri
dc.contributor.authorGe, Jun
dc.contributor.authorLu, Dajiang
dc.contributor.authorZhang, Chenhong
dc.contributor.authorChen, Luonan
dc.contributor.authorCheng, Sulin
dc.date.accessioned2022-08-17T11:52:02Z
dc.date.available2022-08-17T11:52:02Z
dc.date.issued2022
dc.identifier.citationCheng, R., Wang, L., Le, S., Yang, Y., Zhao, C., Zhang, X., Yang, X., Xu, T., Xu, L., Wiklund, P., Ge, J., Lu, D., Zhang, C., Chen, L., & Cheng, S. (2022). A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. <i>Nature Communications</i>, <i>13</i>, Article 2555. <a href="https://doi.org/10.1038/s41467-022-29968-0" target="_blank">https://doi.org/10.1038/s41467-022-29968-0</a>
dc.identifier.otherCONVID_148930177
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82666
dc.description.abstractExercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Communications
dc.rightsCC BY 4.0
dc.titleA randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202208174208
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-1723
dc.relation.volume13
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2022
dc.rights.accesslevelopenAccessfi
dc.subject.ysosatunnaistetut vertailukokeet
dc.subject.ysointerventiotutkimus
dc.subject.ysoei-alkoholiperäinen rasvamaksasairaus
dc.subject.ysoravitsemushoito
dc.subject.ysosuolistomikrobisto
dc.subject.ysoliikuntahoito
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p38295
jyx.subject.urihttp://www.yso.fi/onto/yso/p32625
jyx.subject.urihttp://www.yso.fi/onto/yso/p38728
jyx.subject.urihttp://www.yso.fi/onto/yso/p6589
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p7811
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.datasethttps://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA757939
dc.relation.doi10.1038/s41467-022-29968-0
jyx.fundinginformationFunding to S.C. was provided by the China State Sport General Administration (2013B040, 2015B039), the National Natural Science Foundation of China (Nos. 31571219), the Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013), and to S.L. the Interdisciplinary Program of Shanghai Jiao Tong University (ZH2018QNB05). Funding to L.C. was supported by the National Key R&D Program of China (No. 2017YFA0505500), Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB38040400), National Natural Science Foundation of China (Nos. 31930022, 31771476, 12026608). Funding to C.Z. was supported by the National Natural Science Foundation of China (Nos. 31930022 and 81871091).
dc.type.okmA1


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