Show simple item record

dc.contributor.authorEriksson, Mia D.
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorKorhonen, Päivi
dc.contributor.authorSalonen, Minna K.
dc.contributor.authorMikkola, Tuija M.
dc.contributor.authorKajantie, Eero
dc.contributor.authorWasenius, Niko S.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorLaine, Merja K.
dc.date.accessioned2022-06-15T05:42:38Z
dc.date.available2022-06-15T05:42:38Z
dc.date.issued2022
dc.identifier.citationEriksson, M. D., Eriksson, J. G., Korhonen, P., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N. S., von Bonsdorff, M., Kautiainen, H., & Laine, M. K. (2022). Non-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study. <i>Scientific Reports</i>, <i>12</i>, Article 6987. <a href="https://doi.org/10.1038/s41598-022-10592-3" target="_blank">https://doi.org/10.1038/s41598-022-10592-3</a>
dc.identifier.otherCONVID_147091966
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/81705
dc.description.abstractThere is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. We hypothesized that non-melancholic depressive symptoms have a stronger relationship with both body composition (lean mass and fat mass) and dysfunctional glucose metabolism than melancholic depression. For this cross-sectional study 1510 participants from the Helsinki Birth Cohort Study had their body composition evaluated as lean mass and fat mass (Lean Mass Index [LMI, kg/m2] + Fat Mass Index [FMI kg/m2] = Body Mass Index). Participants were evaluated for depressive symptoms utilizing the Beck depression inventory, and had laboratory assessments including an oral glucose tolerance test. Higher than average FMI was associated with a higher percentage (mean [%], 95% CI) of participants scoring in the depressive range of the Beck depression inventory (20.2, 17.2–23.2) compared to those with low FMI (16.3, 13.8–18.9; p = 0.048) when adjusted for age, sex, education, and fasting plasma glucose concentration. Higher FMI was associated with a higher likelihood of having depressive symptoms (OR per 1-SD FMI = 1.37, 95% CI 1.13–1.65), whereas higher LMI was associated with a lower likelihood of having depressive symptoms (OR per 1-SD LMI = 0.76, 95% CI 0.64–0.91). Participants with an above average FMI more frequently (mean [%], 95% CI) had non-melancholic depressive symptoms (14.7, 11.8–17.7) as compared to those with low FMI (9.7, 7.6–11.9; p = 0.008) regardless of LMI levels. There was no difference between the body composition groups in the likelihood of having melancholic depressive symptoms. The non-melancholic group had higher (mean [kg/m2], SD) FMI (9.6, 4.1) than either of the other groups (BDI < 10: 7.7, 3.1; melancholic: 7.9, 3.6; p < 0.001), and a higher (mean [mmol/l], SD) 2-h glucose concentration (7.21, 1.65) than the non-depressed group (6.71, 1.70; p = 0.005). As hypothesized, non-melancholic depressive symptoms are most closely related to high fat mass index and dysfunctional glucose metabolism.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.othermedical research
dc.subject.othermetabolism
dc.subject.otherneurophysiology
dc.subject.otherpsychology
dc.subject.otherrisk factors
dc.subject.othersigns and symptoms
dc.titleNon-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202206153315
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.volume12
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysokehonkoostumus
dc.subject.ysoglukoosiaineenvaihdunta
dc.subject.ysokohorttitutkimus
dc.subject.ysoaineenvaihdunta
dc.subject.ysoaineenvaihduntahäiriöt
dc.subject.ysomasennus
dc.subject.ysomielenterveyshäiriöt
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p39093
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p6239
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
jyx.subject.urihttp://www.yso.fi/onto/yso/p990
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-022-10592-3
jyx.fundinginformationThe HBCS has been supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072, 210595, 213225, 263924, 275074 and 315690), Samfundet Folkhälsan, Liv och Hälsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth Cohort Study), European Commission, Horizon2020 award 733280 RECAP, Foundation for Cardiovascular Research, Foundation for Diabetes Research, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation.
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0