Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study
Eriksson, M. D., Eriksson, J. G., Kautiainen, H., Salonen, M. K., Mikkola, T. M., Kajantie, E., Wasenius, N., von Bonsdorff, M., & Laine, M. K. (2021). Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms : Findings from Helsinki birth cohort study. Journal of Psychosomatic Research, 145, Article 110488. https://doi.org/10.1016/j.jpsychores.2021.110488
Published inJournal of Psychosomatic Research
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusGerontology and Public HealthGerontology Research Center
© 2021 The Author(s). Published by Elsevier Inc.
Background Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms. Methods From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex. Results Of women, 27% scored ≥10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model. Conclusions The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingThe HBCS has been supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072, 210595, 213225, 263924, 275074 and 315690), Samfundet Folkhälsan, Liv och Hälsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth Cohort Study), European Commission, Horizon2020 award 733280 RECAP), Foundation for Cardiovascular Research, Foundation for Diabetes Research, Foundation for Pediatric Research, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation. ...
Showing items with similar title or keywords.
Higher carotid-radial pulse wave velocity is associated with non-melancholic depressive symptoms in men : findings from Helsinki Birth Cohort Study Eriksson, Mia D.; Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero; Wasenius, Niko; von Bonsdorff, Mikaela; Korhonen, Päivi; Laine, Merja K. (Taylor & Francis, 2021)Background: Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic ...
Non-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study Eriksson, Mia D.; Eriksson, Johan G.; Korhonen, Päivi; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; Laine, Merja K. (Nature Publishing Group, 2022)There is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. ...
Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children Haapala, Eero A.; Väistö, Juuso; Ihalainen, Johanna K.; Tomaselli González, Claudia; Leppänen, Marja H.; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; Brage, Soren; Atalay, Mustafa; Lakka, Timo A. (Taylor & Francis, 2022)We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light ...
Does baseline leisure-time physical activity level predict future depressive symptoms or physical activity among depressive patients? Findings from a Finnish five-year cohort study Raatikainen, Ilkka; Mäntyselkä, Pekka; Heinonen, Ari; Vanhala, Mauno; Kautiainen, Hannu; Koponen, Hannu; Korniloff, Katariina (Taylor & Francis, 2021)Objectives: The aims of this study were to investigate whether baseline leisure-time physical activity (LTPA) is associated with future recovery from depression among patients with a depression diagnosis and whether baseline ...
Inflammatory Biomarkers in Elite Cross-Country Skiers After a Competition Season : A Case-Control Study Luoto, Raakel; Ruuskanen, Olli; Ihalainen, Johanna K.; Pekkala, Satu; Hintikka, Jukka; Kanerva, Noora; Waris, Matti; Heinonen, Olli J.; Valtonen, Maarit (Springer, 2022)Purpose Whether elite athletes, who have been exposed to vigorous-intensity exercise combined with other stressors, have elevated systemic low-grade inflammation, remains largely unclear. To address this question, we ...