dc.contributor.author | Le, S. | |
dc.contributor.author | Zhang, Y. | |
dc.contributor.author | Voutilainen, A. | |
dc.contributor.author | Tan, X. | |
dc.contributor.author | Laukkanen, J. | |
dc.contributor.author | Wang, C. | |
dc.contributor.author | Cheng, S. | |
dc.date.accessioned | 2022-05-24T06:58:16Z | |
dc.date.available | 2022-05-24T06:58:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Le, S., Zhang, Y., Voutilainen, A., Tan, X., Laukkanen, J., Wang, C., & Cheng, S. (2022). Differences in cardiometabolic risk profiles between Chinese and Finnish older adults with glucose impairment and central obesity. <i>Journal of Endocrinological Investigation</i>, <i>45</i>(7), 1427-1437. <a href="https://doi.org/10.1007/s40618-022-01777-8" target="_blank">https://doi.org/10.1007/s40618-022-01777-8</a> | |
dc.identifier.other | CONVID_144392429 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/81238 | |
dc.description.abstract | Background
Obesity and ethnicity play important roles in cardiovascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to compare cardiometabolic risk profiles between Chinese and Finnish older adults of central obesity with prediabetes or T2DM.
Methods
Study subjects were 60–74 years old and originated from two population samples. The Finnish subjects came from the Kuopio Ischemic Heart Disease (KIHD) study (n = 1089), and the Chinese subjects came from the Shanghai High-risk Diabetic Screen (SHiDS) study (n = 818). The KIHD and SHiDS studies used similar questionnaires to determine participants’ baseline characteristics regarding the history of medication use and diseases and lifestyle factors. All study subjects participated in glucose tolerance tests and anthropometry assessments, including waist circumference measurements.
Results
Among study subjects of central obesity with prediabetes (n = 298), fasting and 2-h glucose, and fasting insulin and insulin resistance were significantly higher in Chinese than in Finnish (p < 0.0001–0.016). In addition, triglyceride (TG) level was higher and the low-density lipoprotein cholesterol (LDL) and LDL to high-density lipoprotein cholesterol (HDL) ratio were lower in Chinese than in Finnish (p < 0.0001–0.003). Among subjects of central obesity with T2DM (n = 251), Chinese subjects had significantly less proportions of antihypertensive, glycaemic control medication, and statin users as well as lower level of physical activity (p < 0.0001 for all), while higher blood pressure (p = 0.002 for systolic blood pressure and p < 0.0001 for diastolic blood pressure), TG levels (p < 0.05) and HDL (p = 0.002) than the Finnish counterparts. There were no differences in β-cell function (HOMA-β) between Chinese and Finnish both in prediabetes and T2DM.
Conclusions
Our results indicated that Chinese and Finnish older adults of central obesity with prediabetes and T2DM had similar β-cell function. However, Chinese individuals with prediabetes are prone to insulin resistance. Meanwhile, lipid metabolism dysfunction is also different between Chinese and Finnish. Chinese older adults of central obesity with prediabetes showed higher TG, but Finnish showed higher LDL and LDL/HDL. Strategic for T2DM prevention and treatment should be ethnically specific. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC; Italian Society of Endocrinology | |
dc.relation.ispartofseries | Journal of Endocrinological Investigation | |
dc.rights | CC BY 4.0 | |
dc.subject.other | Type 2 diabetes mellitus | |
dc.subject.other | Chinese | |
dc.subject.other | Finnish | |
dc.subject.other | ethnicity | |
dc.subject.other | central obesity | |
dc.subject.other | cardiovascular disease risk | |
dc.title | Differences in cardiometabolic risk profiles between Chinese and Finnish older adults with glucose impairment and central obesity | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202205242868 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 1427-1437 | |
dc.relation.issn | 0391-4097 | |
dc.relation.numberinseries | 7 | |
dc.relation.volume | 45 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Author(s) 2022 | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | sydän- ja verisuonitaudit | |
dc.subject.yso | suomalaiset | |
dc.subject.yso | lihavuus | |
dc.subject.yso | riskitekijät | |
dc.subject.yso | kiinalaiset | |
dc.subject.yso | aikuistyypin diabetes | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p9886 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3180 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p823 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p13277 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p19668 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p8303 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1007/s40618-022-01777-8 | |
jyx.fundinginformation | Open Access funding provided by University of Jyväskylä (JYU). This work was partly supported by the National Natural Science Foundation of China (NSFC 81770883, 82070913), the Research Start-up Fund from Shanghai Fourth People's Hospital (sykyqd01801), the Shanghai Science and Technology Development Fund (20ZR1446000), the Shanghai Municipal Science and Technology Major Project (2021SHZDZX0100), and the Fundamental Research Funds for the Central Universities. | |
dc.type.okm | A1 | |