dc.contributor.author | Elomaa, Hanna | |
dc.contributor.author | Ahtiainen, Maarit | |
dc.contributor.author | Väyrynen, Sara A. | |
dc.contributor.author | Ogino, Shuji | |
dc.contributor.author | Nowak, Jonathan A. | |
dc.contributor.author | Friman, Marjukka | |
dc.contributor.author | Helminen, Olli | |
dc.contributor.author | Wirta, Erkki-Ville | |
dc.contributor.author | Seppälä, Toni T. | |
dc.contributor.author | Böhm, Jan | |
dc.contributor.author | Mäkinen, Markus J. | |
dc.contributor.author | Mecklin, Jukka-Pekka | |
dc.contributor.author | Kuopio, Teijo | |
dc.contributor.author | Väyrynen, Juha P. | |
dc.date.accessioned | 2022-04-27T07:54:55Z | |
dc.date.available | 2022-04-27T07:54:55Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Ogino, S., Nowak, J. A., Friman, M., Helminen, O., Wirta, E.-V., Seppälä, T. T., Böhm, J., Mäkinen, M. J., Mecklin, J.-P., Kuopio, T., & Väyrynen, J. P. (2022). Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer. <i>British Journal of Cancer</i>, <i>127</i>(3), 514-523. <a href="https://doi.org/10.1038/s41416-022-01822-6" target="_blank">https://doi.org/10.1038/s41416-022-01822-6</a> | |
dc.identifier.other | CONVID_118886155 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/80749 | |
dc.description.abstract | BACKGROUND: Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell colocalisation and T cell densities.
METHODS: We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score).
RESULTS: High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20–0.52, Ptrend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05–0.45, Ptrend < 0.0001] and its prognostic value was independent of T cell density score.
CONCLUSIONS: The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation.ispartofseries | British Journal of Cancer | |
dc.rights | CC BY 4.0 | |
dc.subject.other | cancer microenvironment | |
dc.subject.other | colorectal cancer | |
dc.subject.other | tumour immunology | |
dc.title | Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202204272422 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 514-523 | |
dc.relation.issn | 0007-0920 | |
dc.relation.numberinseries | 3 | |
dc.relation.volume | 127 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2022 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | kasvaimet | |
dc.subject.yso | syöpätaudit | |
dc.subject.yso | immunohistokemia | |
dc.subject.yso | paksusuolisyöpä | |
dc.subject.yso | T-imusolut | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2299 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p678 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p26144 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5937 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p38968 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1038/s41416-022-01822-6 | |
jyx.fundinginformation | This study was funded by Cancer Foundation Finland (59-5619 to JPV). SO’s effort was supported in part by a U.S. National Institutes of Health grant (R35 CA197735). | |
dc.type.okm | A1 | |