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Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes

dc.contributor.authorFachada, Vasco
dc.contributor.authorRahkila, Paavo
dc.contributor.authorFachada, Nuno
dc.contributor.authorTurpeinen, Tuomas
dc.contributor.authorKujala, Urho M.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2022-04-06T04:59:24Z
dc.date.available2022-04-06T04:59:24Z
dc.date.issued2022
dc.identifier.citationFachada, V., Rahkila, P., Fachada, N., Turpeinen, T., Kujala, U. M., & Kainulainen, H. (2022). Enlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes. <i>Acta Histochemica</i>, <i>124</i>(3), Article 151869. <a href="https://doi.org/10.1016/j.acthis.2022.151869" target="_blank">https://doi.org/10.1016/j.acthis.2022.151869</a>
dc.identifier.otherCONVID_117610801
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/80495
dc.description.abstractSkeletal muscle physiology remains of paramount importance in understanding insulin resistance. Due to its high lipid turnover rates, regulation of intramyocellular lipid droplets (LDs) is a key factor. Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. We examined area fraction, size, subcellular localization and PLIN5 association of LDs in two fiber types of type 2 diabetic (T2D), obese (OB) and healthy (HC) individuals by means of fluorescence microscopy and image analysis. We found that T2D type II fibers have a significant sub-population of large and internalized LDs, uncoated by PLIN5. Based on this novel result, additional hypotheses for the pathophysiology of skeletal muscle insulin resistance are formulated, together with future research directions.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier GmbH.
dc.relation.ispartofseriesActa Histochemica
dc.rightsCC BY 4.0
dc.subject.otherlipid droplets
dc.subject.otherPLIN5
dc.subject.otherType II diabetes
dc.subject.otherskeletal muscle
dc.subject.otherinsulin resistance
dc.subject.otherfiber type
dc.titleEnlarged PLIN5-uncoated lipid droplets in inner regions of skeletal muscle type II fibers associate with type 2 diabetes
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202204062177
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFysiikan laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Physicsen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn0065-1281
dc.relation.numberinseries3
dc.relation.volume124
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Author(s). Published by Elsevier GmbH.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber298875
dc.subject.ysoaikuistyypin diabetes
dc.subject.ysoinsuliiniresistenssi
dc.subject.ysoproteiinit
dc.subject.ysolipidit
dc.subject.ysolihakset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p8303
jyx.subject.urihttp://www.yso.fi/onto/yso/p22290
jyx.subject.urihttp://www.yso.fi/onto/yso/p4332
jyx.subject.urihttp://www.yso.fi/onto/yso/p4799
jyx.subject.urihttp://www.yso.fi/onto/yso/p2784
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.acthis.2022.151869
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundinginformationThis study was supported by the Academy of Finland (grant 132987 and 298875) and Fundação para a Ciência e a Tecnologia (FCT, Portugal) under grant UIDB/04111/2020 (COPELABS). The author Vasco Fachada acknowledges his FCT grant SFRH/BD/68308/2010.
dc.type.okmA1


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