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dc.contributor.authorNurmi, Timo
dc.contributor.authorJaatela, Julia
dc.contributor.authorVallinoja, Jaakko
dc.contributor.authorMäenpää, Helena
dc.contributor.authorPiitulainen, Harri
dc.date.accessioned2021-09-01T06:35:05Z
dc.date.available2021-09-01T06:35:05Z
dc.date.issued2021
dc.identifier.citationNurmi, T., Jaatela, J., Vallinoja, J., Mäenpää, H., & Piitulainen, H. (2021). Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral palsy. <i>NeuroImage: Clinical</i>, <i>32</i>, Article 102795. <a href="https://doi.org/10.1016/j.nicl.2021.102795" target="_blank">https://doi.org/10.1016/j.nicl.2021.102795</a>
dc.identifier.otherCONVID_100270042
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/77619
dc.description.abstractCerebral palsy (CP) is a motor disorder where the motor defects are partly due to impaired proprioception. We studied cortical proprioceptive responses and sensorimotor performance in adolescents with CP and their typically-developed (TD) peers. Passive joint movements were used to stimulate proprioceptors during functional magnetic resonance imaging (fMRI) session to quantify the proprioceptive responses whose associations to behavioral sensorimotor performance were also examined. Twenty-three TD (15 females, age: mean ± standard deviation 14.2 ± 2.4 years) and 18 CP (12 females, age: mean ± standard deviation, 13.8 ± 2.3 years; 12 hemiplegic, 6 diplegic) participants were included in this study. Participants’ index fingers and ankles were separately stimulated at 3 Hz and 1 Hz respectively with pneumatic movement actuators. Regions-of-interest were used to quantify BOLD-responses from the primary sensorimotor (SM1) and secondary (SII) somatosensory cortices and were compared across the groups. Associations between responses strengths and sensorimotor performance measures were also examined. Proprioceptive responses were stronger for the individuals with CP compared to their TD peers in SM1 (p < 0.001) and SII (p < 0.05) cortices contralateral to their more affected index finger. The ankle responses yielded no significant differences between the groups. The CP group had worse sensorimotor performance for hands and feet (p < 0.001). Stronger responses to finger stimulation in the dominant SM1 (p < 0.001) and both dominant and non-dominant SII (p < 0.01, p < 0.001) cortices were associated with the worse hand sensorimotor performance across all participants. Worse hand function was associated with stronger cortical activation to the proprioceptive stimulation. This association was evident both in adolescents with CP and their typically-developed controls, thus it likely reflects both clinical factors and normal variation in the sensorimotor function. The specific mechanisms need to be clarified in future studies.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesNeuroImage: Clinical
dc.rightsCC BY 4.0
dc.subject.otherpassive movement
dc.subject.otherSI
dc.subject.otherSII
dc.subject.otherkinesthesia
dc.subject.otherhemiplegia
dc.subject.otherdiplegia
dc.titleStronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral palsy
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202109014745
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn2213-1582
dc.relation.volume32
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Author(s). Published by Elsevier Inc.
dc.rights.accesslevelopenAccessfi
dc.subject.ysohalvaus
dc.subject.ysohemiplegia
dc.subject.ysoliikeaisti
dc.subject.ysoCP-oireyhtymä
dc.subject.ysotuntoaisti
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p10764
jyx.subject.urihttp://www.yso.fi/onto/yso/p18956
jyx.subject.urihttp://www.yso.fi/onto/yso/p23334
jyx.subject.urihttp://www.yso.fi/onto/yso/p13394
jyx.subject.urihttp://www.yso.fi/onto/yso/p3330
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.nicl.2021.102795
jyx.fundinginformationThis work was supported by the Academy of Finland (grants #296240, #304294, #307250 to HP); Jane and Aatos Erkko Foundation and Emil Aaltonen Foundation to HP.


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