Dean effect in particle sorting
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2021Copyright
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Tässä tutkielma suunniteltiin ja valmistettiin partikkelien lajitteluun tarkoitettu laite. Kyseinen laite hyödyntää toiminnassaan hydrodynaamisia voimia ja Deanin efektiä. Partikkelit saadaan eroteltua niiden koon perusteella. Laitetta voidaan hyödyntää partikkelien konsentraation kasvattamiseen. Laite on puolentoistakierroksen mallinenspiraalikuvio ja se valmistetaan PDMS:stä. Tutkimuksessa lajiteltiin 31,5 μm, 14,3 μm ja 5,1 μm kokoluokan muovipartikkeleita. 94% isoimman kokoisista partikkeleista saatiin kerättyä. Tuloksia voitaisiin parantaa muokkaamalla mittausasetelmasta kattavampi tai kuvankäsittelystä tarkempi. Tulevaisuudessa laitetta voitaisiin hyödyntää syöpäsolujen erottamiseen verinäytteistä tai muihin biologisiin ja lääketieteellisiin sovelluskohteisiin. A particle sorting device was made in this study with the particles being separated according to their size. This type of device can be utilised in applications requiring enrichment or concentration. The device designed is fabricated from PDMS and it has a 1.5-loop spiral geometry. The sorting is caused by hydrodynamic forces acting on the particles flowing in a microchannel. Dean effect, caused by curvature of the channel, enhances the separation. It leads to 31.5 μm sized particles to be sorted from 14.3 μm and 5.1 μm sized particles. With the plastic particles, the device demonstrated a separation efficiency of up to 94%. The results could be improved by additional components for the device or the set-up, and by modifying the image analysis script. Optimising the conditions further, the device could be applied to circulating tumour cell separation, or other biological and medical applications.
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