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dc.contributor.authorJernfors, Toni
dc.contributor.authorDanforth, John
dc.contributor.authorKesäniemi, Jenni
dc.contributor.authorLavrinienko, Anton
dc.contributor.authorTukalenko, Eugene
dc.contributor.authorFajkus, Jiří
dc.contributor.authorDvořáčková, Martina
dc.contributor.authorMappes, Tapio
dc.contributor.authorWatts, Phillip C.
dc.date.accessioned2021-06-02T06:32:01Z
dc.date.available2021-06-02T06:32:01Z
dc.date.issued2021
dc.identifier.citationJernfors, T., Danforth, J., Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Fajkus, J., Dvořáčková, M., Mappes, T., & Watts, P. C. (2021). Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides. <i>Ecology and Evolution</i>, <i>11</i>(13), 8754-8767. <a href="https://doi.org/10.1002/ece3.7684" target="_blank">https://doi.org/10.1002/ece3.7684</a>
dc.identifier.otherCONVID_89759677
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/76134
dc.description.abstractAltered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles (Myodes glareolus) inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations. Moreover, 18S rDNA and Msat-160 copy number were positively correlated in the genomes of bank voles from uncontaminated, but not in the genomes of animals inhabiting contaminated, areas. These results show the capacity for local-scale geographic variation in genome architecture and are consistent with the genomic safeguard hypothesis. Disruption of cellular processes related to genomic stability appears to be a hallmark effect in bank voles inhabiting areas contaminated by radionuclides.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofseriesEcology and Evolution
dc.rightsCC BY 4.0
dc.subject.otheranthropogenic disturbance
dc.subject.otherChernobyl
dc.subject.othercopy number
dc.subject.otherionizing radiation
dc.subject.otherMyodes glareolus
dc.subject.otherrDNA
dc.titleExpansion of rDNA and pericentromere satellite repeats in the genomes of bank voles Myodes glareolus exposed to environmental radionuclides
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202106023370
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange8754-8767
dc.relation.issn2045-7758
dc.relation.numberinseries13
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber324602
dc.relation.grantnumber268670
dc.relation.grantnumber324605
dc.subject.ysoionisoiva säteily
dc.subject.ysometsämyyrä
dc.subject.ysoluonnonvaraiset eläimet
dc.subject.ysoTšernobylin ydinonnettomuus
dc.subject.ysoDNA
dc.subject.ysosäteilybiologia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p459
jyx.subject.urihttp://www.yso.fi/onto/yso/p513
jyx.subject.urihttp://www.yso.fi/onto/yso/p6917
jyx.subject.urihttp://www.yso.fi/onto/yso/p29517
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
jyx.subject.urihttp://www.yso.fi/onto/yso/p1781
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1002/ece3.7684
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis work was supported by the Finnish Academy (287153, 324602 to PCW and 268670, 324605 to TM) and the Finnish Cultural Foundation to TJ.


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