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dc.contributor.authorSievänen, Tero
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorLaakkonen, Eija K.
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorPylvänäinen, Kirsi
dc.contributor.authorSeppälä, Toni T.
dc.contributor.authorPeltomäki, Päivi
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorSillanpää, Elina
dc.date.accessioned2021-04-16T07:44:52Z
dc.date.available2021-04-16T07:44:52Z
dc.date.issued2021
dc.identifier.citationSievänen, T., Törmäkangas, T., Laakkonen, E. K., Mecklin, J.-P., Pylvänäinen, K., Seppälä, T. T., Peltomäki, P., Sipilä, S., & Sillanpää, E. (2021). Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome. <i>Cancers</i>, <i>13</i>(8), Article 1849. <a href="https://doi.org/10.3390/cancers13081849" target="_blank">https://doi.org/10.3390/cancers13081849</a>
dc.identifier.otherCONVID_66411356
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/75079
dc.description.abstractLynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesCancers
dc.rightsCC BY 4.0
dc.subject.otherepidemiology
dc.subject.otherhereditary non-polyposis colorectal cancer
dc.subject.otherlifestyle
dc.titleBody Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104162388
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2072-6694
dc.relation.numberinseries8
dc.relation.volume13
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights.accesslevelopenAccessfi
dc.subject.ysosuolistosyövät
dc.subject.ysoepidemiologia
dc.subject.ysoylipaino
dc.subject.ysoLynchin oireyhtymä
dc.subject.ysoelintavat
dc.subject.ysoriskitekijät
dc.subject.ysoperinnölliset taudit
dc.subject.ysofyysinen aktiivisuus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p25845
jyx.subject.urihttp://www.yso.fi/onto/yso/p11307
jyx.subject.urihttp://www.yso.fi/onto/yso/p826
jyx.subject.urihttp://www.yso.fi/onto/yso/p23697
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p19997
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/cancers13081849
jyx.fundinginformationThis research was funded by the Cancer Society Finland, iCAN Flagship of the Finnish Academy, Emil Aaltonen Foundation, Finnish Medical Foundation, Sigrid Juselius Foundation, Instrumentarium Science Foundation, and Jane and Aatos Erkko Foundation. There are no unique identifiers, or grant numbers, associated with the granted funds
datacite.isSupplementedBy.doi10.17011/jyx/dataset/93204
datacite.isSupplementedByLaakkonen, Eija; Seppälä, Toni; Mecklin, Jukka-Pekka. (2024). <i>Lynch Syndrome, lifestyle habits and biomarkers</i>. University of Jyväskylä. <a href="https://doi.org/10.17011/jyx/dataset/93204" target="_blank">https://doi.org/10.17011/jyx/dataset/93204</a>. <a href="http://urn.fi/URN:NBN:fi:jyu-202402011711">https://urn.fi/URN:NBN:fi:jyu-202402011711</a>
dc.type.okmA1


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