Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome
Sievänen, T., Törmäkangas, T., Laakkonen, E. K., Mecklin, J.-P., Pylvänäinen, K., Seppälä, T. T., Peltomäki, P., Sipilä, S., & Sillanpää, E. (2021). Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome. Cancers, 13(8), Article 1849. https://doi.org/10.3390/cancers13081849
Julkaistu sarjassa
CancersTekijät
Päivämäärä
2021Tekijänoikeudet
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS.
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Julkaisija
MDPI AGISSN Hae Julkaisufoorumista
2072-6694Asiasanat
Julkaisuun liittyvä(t) tutkimusaineisto(t)
Laakkonen, Eija; Seppälä, Toni; Mecklin, Jukka-Pekka. (2024). Lynch Syndrome, lifestyle habits and biomarkers. University of Jyväskylä. https://doi.org/10.17011/jyx/dataset/93204. https://urn.fi/URN:NBN:fi:jyu-202402011711Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/66411356
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Lisätietoja rahoituksesta
This research was funded by the Cancer Society Finland, iCAN Flagship of the Finnish Academy, Emil Aaltonen Foundation, Finnish Medical Foundation, Sigrid Juselius Foundation, Instrumentarium Science Foundation, and Jane and Aatos Erkko Foundation. There are no unique identifiers, or grant numbers, associated with the granted fundsLisenssi
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Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
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Colorectal cancer incidences in Lynch syndrome : a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
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The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance
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Systemic circulating microRNA landscape in Lynch syndrome
Sievänen, Tero; Korhonen, Tia‐Marje; Jokela, Tiina; Ahtiainen, Maarit; Lahtinen, Laura; Kuopio, Teijo; Lepistö, Anna; Sillanpää, Elina; Mecklin, Jukka‐Pekka; Seppälä, Toni T.; Laakkonen, Eija K. (Wiley, 2023)Circulating microRNAs (c-miRs) are small non-coding RNA molecules that migrate throughout the body and regulate gene expression. Global c-miR expression patterns (c-miRnomes) change with sporadic carcinogenesis and have ... -
Circulating microRNAs are a potential molecular link between nutrition and colorectal cancer risk in Lynch Syndrome
Kärkkäinen, Minta (2023)Lynch syndrome is an inherited cancer-predisposing syndrome where occur mutations in mismatch repair genes. Colorectal cancer is a common form of cancer within Lynch syndrome carriers. The inherited gene mutation predisposes ...
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