Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains
Koskinen, K., Penttinen, R., Örmälä-Odegrip, A.-M., Giske, C. G., Ketola, T., & Jalasvuori, M. (2021). Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains. Frontiers in Cellular and Infection Microbiology, 11, Article 599924. https://doi.org/10.3389/fcimb.2021.599924
Julkaistu sarjassa
Frontiers in Cellular and Infection MicrobiologyTekijät
Päivämäärä
2021Oppiaine
Solu- ja molekyylibiologiaEkologia ja evoluutiobiologiaBiologisten vuorovaikutusten huippututkimusyksikköCell and Molecular BiologyEcology and Evolutionary BiologyCentre of Excellence in Biological Interactions ResearchTekijänoikeudet
© 2021 the Authors
Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic carbapenem resistant K. pneumoniae isolates for extensive systematic characterization for phenotypic and genotypic qualities in order to identify potential factors that precede or emerge from epidemic successfulness. Studied characteristics include growth rates and densities in different conditions (media, temperature, pH, resource levels), tolerance to alcohol and drought, inhibition between strains, ability to compensate pH, as well as various genomic features. Overall, there are clear differences between isolates, yet, only drought tolerance was found to notably associate with non-epidemic K. pneumoniae strains. We further report a preliminary study on the potential to control K. pneumoniae ST11 with an antimicrobial component produced by a non-epidemic K. pneumoniae. This component initially restricts bacterial growth, but stable resistance develops rapidly in vitro.
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Julkaisija
Frontiers MediaISSN Hae Julkaisufoorumista
2235-2988Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/52395051
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiatutkija, SA; Muut, SALisätietoja rahoituksesta
Authors wish to acknowledge funding from the Academy of Finland (grants no.252411, no.297049 and no. 336518 to MJ and no. 322204 to RP), Emil Aaltonen Foundation and Jane and Aatos Erkko Foundation.Lisenssi
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