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dc.contributor.authorKallio, Petri
dc.contributor.authorPahkala, Katja
dc.contributor.authorHeinonen, Olli J.
dc.contributor.authorTammelin, Tuija H.
dc.contributor.authorPälve, Kristiina
dc.contributor.authorHirvensalo, Mirja
dc.contributor.authorJuonala, Markus
dc.contributor.authorLoo, Britt-Marie
dc.contributor.authorMagnussen, Costan G.
dc.contributor.authorRovio, Suvi
dc.contributor.authorHelajärvi, Harri
dc.contributor.authorLaitinen, Tomi P.
dc.contributor.authorJokinen, Eero
dc.contributor.authorTossavainen, Päivi
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorViikari, Jorma
dc.contributor.authorRaitakari, Olli T.
dc.date.accessioned2021-02-12T11:42:25Z
dc.date.available2021-02-12T11:42:25Z
dc.date.issued2021
dc.identifier.citationKallio, P., Pahkala, K., Heinonen, O. J., Tammelin, T. H., Pälve, K., Hirvensalo, M., Juonala, M., Loo, B.-M., Magnussen, C. G., Rovio, S., Helajärvi, H., Laitinen, T. P., Jokinen, E., Tossavainen, P., Hutri-Kähönen, N., Viikari, J., & Raitakari, O. T. (2021). Physical inactivity from youth to adulthood and adult cardiometabolic risk profile. <i>Preventive Medicine</i>, <i>145</i>, Article 106433. <a href="https://doi.org/10.1016/j.ypmed.2021.106433" target="_blank">https://doi.org/10.1016/j.ypmed.2021.106433</a>
dc.identifier.otherCONVID_47874815
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74204
dc.description.abstractAdults with a low physical activity (PA) level are at increased risk for cardiometabolic diseases, but little is known on the association between physical inactivity since youth and cardiometabolic health in adulthood. We investigated the association of persistent physical inactivity from youth to adulthood with adult cardiometabolic risk factors. Data were drawn from the ongoing Cardiovascular Risk in Young Finns Study with seven follow-ups between 1980 and 2011 (baseline age 3–18 years, n = 1961). Physical activity data from a standardized questionnaire was expressed as a PA-index. Using the PA-index, four groups were formed: 1)persistently physically inactive (n = 246), 2)decreasingly active (n = 305), 3)increasingly active (n = 328), and 4)persistently active individuals (n = 1082). Adulthood cardiometabolic risk indicators included waist circumference, body mass index (BMI), blood pressure, and fasting lipids, insulin, and glucose. Clustered cardiometabolic risk was defined using established criteria for metabolic syndrome. Persistently physically inactive group was used as a reference. Compared to the persistently physically inactive group, those who were persistently active had lower risk for adult clustered cardiometabolic risk (RR = 0.67;CI95% = 0.53–0.84; Harmonized criteria), obesity (BMI > 30 kg/m2, RR = 0.76;CI95% = 0.59–0.98), high waist circumference (RR = 0.82;CI95% = 0.69–0.98), and high triglyceride (RR = 0.60;CI95% = 0.47–0.75), insulin (RR = 0.58;CI95% = 0.46–0.74) and glucose (RR = 0.77;CI95% = 0.62–0.96) concentrations as well as low high-density lipoprotein cholesterol (HDLsingle bondC) concentration (RR = 0.78;CI95% = 0.66–0.93). Comparable results were found when persistently physically inactive individuals were compared with those who increased PA. The results remained essentially similar after adjustment for education, diet, smoking, and BMI. Persistently physically inactive lifestyle since youth is associated with an unfavorable cardiometabolic risk profile in adulthood. Importantly, even minor increase in PA lowers the cardiometabolic risk.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesPreventive Medicine
dc.rightsCC BY-NC-ND 4.0
dc.subject.othercardiovascular
dc.subject.otherCVD: childhood
dc.subject.otherinactive lifestyle
dc.subject.otherlongitudinal
dc.titlePhysical inactivity from youth to adulthood and adult cardiometabolic risk profile
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202102121632
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntapedagogiikkafi
dc.contributor.oppiaineSport Pedagogyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0091-7435
dc.relation.volume145
dc.type.versionacceptedVersion
dc.rights.copyright© 2021 Elsevier Inc. All rights reserved.
dc.rights.accesslevelopenAccessfi
dc.subject.ysolapsuus
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysopitkittäistutkimus
dc.subject.ysoterveysriskit
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysonuoruus
dc.subject.ysoelintavat
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13735
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p14610
jyx.subject.urihttp://www.yso.fi/onto/yso/p11098
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p15327
jyx.subject.urihttp://www.yso.fi/onto/yso/p5530
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.ypmed.2021.106433
jyx.fundinginformationThe Cardiovascular Risk in Young Finns Study was financially supported by the Academy of Finland (grants 286284 [to T.L.]; 134309 [Eye]; 126925, 121584, 124282, and 129378 [Salve]; 117787 [Gendi]; 41071 [Skidi]; 275595, 233112 [to K.P.]); Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds (grant X51001 to T.L.); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation of Cardiovascular Research; Finnish Cultural Foundation; Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; and Yrjö Jahnsson Foundation. This work was also partly funded by the National Heart Foundation of Australia Future Leader Fellowship (grant 100849 to C.G.M.) and the National Health and Medical Research Council Project (grant APP1098369).


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