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dc.contributor.authorMehta, Anurag
dc.contributor.authorKondamudi, Nitin
dc.contributor.authorLaukkanen, Jari A.
dc.contributor.authorWisloff, Ulrik
dc.contributor.authorFranklin, Barry A.
dc.contributor.authorArena, Ross
dc.contributor.authorLavie, Carl J.
dc.contributor.authorPandey, Ambarish
dc.date.accessioned2020-12-16T09:41:54Z
dc.date.available2020-12-16T09:41:54Z
dc.date.issued2020
dc.identifier.citationMehta, A., Kondamudi, N., Laukkanen, J. A., Wisloff, U., Franklin, B. A., Arena, R., Lavie, C. J., & Pandey, A. (2020). Running away from cardiovascular disease at the right speed : the impact of aerobic physical activity and cardiorespiratory fitness on cardiovascular disease risk and associated subclinical phenotypes. <i>Progress in Cardiovascular Diseases</i>, <i>63</i>(3), 762-774. <a href="https://doi.org/10.1016/j.pcad.2020.11.004" target="_blank">https://doi.org/10.1016/j.pcad.2020.11.004</a>
dc.identifier.otherCONVID_47052622
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/73261
dc.description.abstractHigher levels of physical activity (PA) and cardiorespiratory fitness (CRF) are associated with lower risk of incident cardiovascular disease (CVD). However, the relationship of aerobic PA and CRF with risk of atherosclerotic CVD outcomes and heart failure (HF) seem to be distinct. Furthermore, recent studies have raised concerns of potential toxicity associated with extreme levels of aerobic exercise, with higher levels of coronary artery calcium and incident atrial fibrillation noted among individuals with very high PA levels. In contrast, the relationship between PA levels and measures of left ventricular structure and function and risk of HF is more linear. Thus, personalizing exercise levels to optimal doses may be key to achieving beneficial outcomes and preventing adverse CVD events among high risk individuals. In this report, we provide a comprehensive review of the literature on the associations of aerobic PA and CRF levels with risk of adverse CVD outcomes and the preceding subclinical cardiac phenotypes to better characterize the optimal exercise dose needed to favorably modify CVD risk.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesProgress in Cardiovascular Diseases
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherphysical activity
dc.subject.otherfitness
dc.subject.otherprevention
dc.subject.othercoronary artery disease
dc.subject.otherheart failure
dc.subject.otheratrial fibrillation
dc.titleRunning away from cardiovascular disease at the right speed : the impact of aerobic physical activity and cardiorespiratory fitness on cardiovascular disease risk and associated subclinical phenotypes
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202012167200
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange762-774
dc.relation.issn0033-0620
dc.relation.numberinseries3
dc.relation.volume63
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 Elsevier
dc.rights.accesslevelopenAccessfi
dc.subject.ysoaerobinen harjoittelu
dc.subject.ysokuntoliikunta
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysofyysinen kunto
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysosydämen vajaatoiminta
dc.subject.ysoeteisvärinä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p24767
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p7384
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p18795
jyx.subject.urihttp://www.yso.fi/onto/yso/p21917
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.pcad.2020.11.004
jyx.fundinginformationDr. Pandey is supported by the Texas Health Resources Clinical Scholarship. Dr. Mehta is supported by American Heart Association postdoctoral fellowship award 19POST34400057.


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CC BY-NC-ND 4.0
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