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Physical activity as a protective factor for dementia and Alzheimer’s disease : systematic review, meta-analysis and quality assessment of cohort and case-control studies
Iso-Markku, Paula; Kujala, Urho M; Knittle, Keegan; Polet, Juho; Vuoksimaa, Eero; Waller, Katja (BMJ Publishing Group, 2022)OBJECTIVE - Physical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study ... -
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases : the HUNT study
Tynkkynen, Niko Paavo; Törmäkangas, Timo; Palviainen, Teemu; Hyvärinen, Matti; Klevjer, Marie; Joensuu, Laura; Kujala, Urho; Kaprio, Jaakko; Bye, Anja; Sillanpää, Elina (Springer, 2023)Physical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly heritable multifactorial phenotypes. Shared genetic factors may underlie the associations between higher levels of PA and better aerobic ... -
Dementia in former amateur and professional contact sports participants : population-based cohort study, systematic review, and meta-analysis
Batty, G. David; Frank, Philipp; Kujala, Urho M.; Sarna, Seppo J.; Valencia-Hernández, Carlos A.; Kaprio, Jaakko (Elsevier, 2023)Background Although there is growing evidence that former professional athletes from sports characterised by repetitive head impact subsequently experience an elevated risk of dementia, the occurrence of this disorder in ... -
Handgrip strength and all‐cause dementia incidence and mortality : findings from the UK Biobank prospective cohort study
Esteban‐Cornejo, Irene; Ho, Frederick K.; Petermann‐Rocha, Fanny; Lyall, Donald M.; Martinez‐Gomez, David; Cabanas‐Sánchez, Verónica; Ortega, Francisco B.; Hillman, Charles H.; Gill, Jason M. R.; Quinn, Terence J.; Sattar, Naveed; Pell, Jill P.; Gray, Stuart R.; Celis‐Morales, Carlos (Wiley, 2022)Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total ... -
Associations of Genetic Susceptibility to Alzheimer’s Disease with Adiposity and Cardiometabolic Risk Factors among Children in a 2-Year Follow-up Study
Haapala, Eero; Paananen, Jussi; Hiltunen, Mikko; Lakka, Timo A. (IOS Press, 2018)We investigated the associations of genetic risk score (GRS) for Alzheimer’s disease and apolipoprotein E (APOE) ɛ variant with cardiometabolic risk factors during 2-year follow-up in children and whether body fat percentage ...