dc.contributor.author | Rosa, Thiago Santos | |
dc.contributor.author | Neves, Rodrigo Vanerson Passos | |
dc.contributor.author | Deus, Lysleine Alves | |
dc.contributor.author | Sousa, Caio Victor | |
dc.contributor.author | da Silva Aguiar, Samuel | |
dc.contributor.author | de Souza, Michel Kendy | |
dc.contributor.author | Moraes, Milton Rocha | |
dc.contributor.author | Rosa, Érica Carine Campos Caldas | |
dc.contributor.author | Andrade, Rosangela Vieira | |
dc.contributor.author | Korhonen, Marko T. | |
dc.contributor.author | Simões, Herbert Gustavo | |
dc.date.accessioned | 2020-07-06T09:01:30Z | |
dc.date.available | 2020-07-06T09:01:30Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Rosa, T. S., Neves, R. V. P., Deus, L. A., Sousa, C. V., da Silva Aguiar, S., de Souza, M. K., Moraes, M. R., Rosa, É. C. C. C., Andrade, R. V., Korhonen, M. T., & Simões, H. G. (2020). Sprint and endurance training in relation to redox and inflammatory status and biomarkers of aging in master athletes. <i>Nitric oxide-biology and chemistry</i>, <i>102</i>, 42-51. <a href="https://doi.org/10.1016/j.niox.2020.05.004" target="_blank">https://doi.org/10.1016/j.niox.2020.05.004</a> | |
dc.identifier.other | CONVID_36044076 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/71080 | |
dc.description.abstract | Purpose Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged individuals as controls. Methods Participants were male master sprinters (SA, 50±8.9yrs; n=13) and endurance runners (EA, 53±8.2yrs; n=18) with remarkable athletic experience (∼25yrs of practice), besides untrained young (YC, 22.7±3.9yrs; n=17) and age-matched controls (MC, 45.5±9.8yrs; n=12). Anamnesis, anthropometrics, biomarkers of aging, inflammation status and oxidative stress parameters were analyzed in all participants. Results An increased pro-oxidant activity (elevated protein carbonyl; isoprostanes and 8-OHdG) was observed for MC in comparison to remaining groups (p<0.05). However, SA presented a better antioxidant capacity than both MC and EA, while nitrite/nitrate (NOx) availability was higher for EA and lower for the MC (p<0.05). Both groups of athletes presented a better anti-inflammatory status than MC (increased IL-10 and lowered IL-6, sIL-6R, sTNF-RI), but worse than YC (increased TNF-α, sTNF-RI, and sIL-6R) (p<0.05). Telomere length was shorter in MC, which also had lower levels of irisin and klotho, and elevated FGF-23 (p<0.05). ADMA levels were higher in MC and SA, while irisin was lower in EA when compared to SA and YC (p<0.05). Conclusion Master athletes presented better redox balance and inflammatory status, with decreased biomarkers of aging compared to control. Regarding exercise mode, a better NO- profile, as a marker of endothelial function, was observed for EA, whereas SA had a better redox balance, cytokines profile and attenuated biomarkers of aging. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Nitric oxide-biology and chemistry | |
dc.rights | CC BY-NC-ND 4.0 | |
dc.subject.other | master athletes | |
dc.subject.other | oxidative stress | |
dc.subject.other | cytokines | |
dc.subject.other | klotho-FGF-23 | |
dc.subject.other | irisin | |
dc.subject.other | ADMA | |
dc.title | Sprint and endurance training in relation to redox and inflammatory status and biomarkers of aging in master athletes | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202007065253 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 42-51 | |
dc.relation.issn | 1089-8603 | |
dc.relation.volume | 102 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © 2020 Elsevier Inc. All rights reserved. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | tulehdus | |
dc.subject.yso | kestävyysharjoittelu | |
dc.subject.yso | hapenotto | |
dc.subject.yso | biomarkkerit | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p1049 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p7676 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p25455 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p12288 | |
dc.rights.url | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.relation.doi | 10.1016/j.niox.2020.05.004 | |
jyx.fundinginformation | This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and received grants from the Fundação de Apoio à Pesquisa do Distrito Federal (FAP/DF): Demanda Espontânea – Edital 03/2015 and Demanda Espontânea – Edital 04/2017. | |
dc.type.okm | A1 | |