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dc.contributor.authorVäyrynen, V.
dc.contributor.authorWirta, E
dc.contributor.authorSeppälä, T.
dc.contributor.authorSihvo, E.
dc.contributor.authorMecklin, J-P.
dc.contributor.authorVasala, K.
dc.contributor.authorKellokumpu, I.
dc.date.accessioned2020-06-23T12:35:43Z
dc.date.available2020-06-23T12:35:43Z
dc.date.issued2020
dc.identifier.citationVäyrynen, V., Wirta, E., Seppälä, T., Sihvo, E., Mecklin, J-P., Vasala, K., & Kellokumpu, I. (2020). Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study. <i>BJS Open</i>, <i>4</i>(4), 685-692. <a href="https://doi.org/10.1002/bjs5.50299" target="_blank">https://doi.org/10.1002/bjs5.50299</a>
dc.identifier.otherCONVID_36002975
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/70285
dc.description.abstractBackground This population-based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods A retrospective population-based study was conducted on patients with metastatic colorectal cancer in Central Finland in 2000–2015. Clinical and histopathological data were retrieved and descriptive analysis was conducted to determine the pattern of metastatic disease, defined as synchronous, early metachronous (within 12 months of diagnosis of primary disease) and late metachronous (more than 12 months after diagnosis). Subgroups were compared for resection and overall survival (OS) rates. Results Of 1671 patients, 296 (17·7 per cent) had synchronous metastases, and 255 (19·6 per cent) of 1302 patients with resected stage I–III tumours developed metachronous metastases (94 early and 161 late metastases). Liver, pulmonary and intraperitoneal metastases were the most common sites. The commonest metastatic patterns were a combination of liver and lung metastases. The overall metastasectomy rate for patients with synchronous metastases was 16·2 per cent; in this subgroup, 3- and 5-year OS rates after any resection were 63 and 44 per cent respectively, compared with 7·1 and 3·3 per cent following no resection (P < 0·001). The resection rate was higher for late than for early metachronous disease (28·0 versus 17 per cent respectively; P = 0·048). Three- and 5-year OS rates after any resection of metachronous metastases were 78 and 62 per cent respectively versus 42·1 and 18·2 per cent with no metastasectomy (P < 0·001). Similarly, 3- and 5-year OS rates after any metastasectomy for early metachronous metastases were 57 and 50 per cent versus 84 and 66 per cent for late metachronous metastases (P = 0·293). Conclusion The proportion of patients with metastatic colorectal cancer was consistent with that in earlier population-based studies, as were resection rates for liver and lung metastases and survival after resection. Differentiation between synchronous, early and late metachronous metastases can improve assessment of resectability and survival.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofseriesBJS Open
dc.rightsCC BY 4.0
dc.subject.othercolorectal cancer
dc.titleIncidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202006234477
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange685-692
dc.relation.issn2474-9842
dc.relation.numberinseries4
dc.relation.volume4
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 the Author(s)
dc.rights.accesslevelopenAccessfi
dc.subject.ysosyöpätaudit
dc.subject.ysoetäpesäkkeet
dc.subject.ysoesiintyvyys
dc.subject.ysosuolistosyövät
dc.subject.ysopaksusuolisyöpä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p2298
jyx.subject.urihttp://www.yso.fi/onto/yso/p21428
jyx.subject.urihttp://www.yso.fi/onto/yso/p25845
jyx.subject.urihttp://www.yso.fi/onto/yso/p5937
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1002/bjs5.50299
jyx.fundinginformationNo funding
dc.type.okmA1


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