Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
Karjula, T., Niskakangas, A., Mustonen, O., Puro, I., Elomaa, H., Ahtiainen, M., Kuopio, T., Mecklin, J.-P., Seppälä, T. T., Wirta, E.-V., Sihvo, E., Yannopoulos, F., Helminen, O., & Väyrynen, J. P. (2023). Tertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer. Virchows Archiv, 483, 21-32. https://doi.org/10.1007/s00428-023-03577-8
Julkaistu sarjassa
Virchows ArchivTekijät
Päivämäärä
2023Tekijänoikeudet
© 2023 the Authors
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect of TLSs in colorectal cancer (CRC) pulmonary metastases and primary tumours, with a comparison to the CD3+ and CD8+ cell density-based immune cell score (ICS). For TLS density and TLS maximum diameter analysis, 67 pulmonary metastases and 63 primary tumours were stained with haematoxylin and eosin. For ICS scoring and analysis, CD3 and CD8 immunohistochemistry was performed. Excellent interobserver agreement was achieved in all TLS measurements. Of all patients, 36 patients had low TLS density (< 0.222 follicles/mm) and 31 patients had high TLS density (≥ 0.222 follicles/mm) in the first resected pulmonary metastases. TLS density (adjusted HR 0.91, 0.48–1.73) or maximum diameter (adjusted HR 0.78, 0.40–1.51) did not have prognostic value in pulmonary metastases. In primary tumours, higher TLS density (adjusted HR 0.39, 0.18–0.87) and maximum diameter (adjusted HR 0.28, 0.11–0.73) were associated with lower mortality. In the pulmonary metastases, ICS had superior prognostic value to TLSs; however, TLSs and ICS were significantly associated. In conclusion, TLSs in CRC pulmonary metastases had no prognostic value but correlated with the ICS. TLSs in primary tumours associated with favourable prognosis.
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Julkaisija
SpringerISSN Hae Julkaisufoorumista
0945-6317Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/183656214
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Lisätietoja rahoituksesta
Open Access funding provided by University of Oulu including Oulu University Hospital. This study was funded by Instrumentarium Science Foundation (OH), Mary and Georg C. Ehrnrooth Foundation (OH) and Finnish State Research Funding (OH, J-P.M), Cancer Foundation Finland (J.P.V), J&A Erkko Foundation (J-P.M, TTS).Lisenssi
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CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer
Karjula, Topias; Elomaa, Hanna; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Kuopio, Teijo; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Seppälä, Toni, T.; Wirta, Erkki-Ville; Sihvo, Eero; Väyrynen, Juha, P.; Yannopoulos, Fredrik; Helminen, Olli (MDPI AG, 2023)Simple Summary The lung is the second most common site of metastases in colorectal cancer (CRC). The aim of our study was to evaluate the prognostic value of CD3+ and CD8+ T-cell density based immune cell score (ICS) ... -
The prognostic role of tumor budding and tumor-stroma ratio in pulmonary metastasis of colorectal carcinoma
Karjula, Topias; Kemi, Niko; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Pohjanen, Vesa-Matti; Kuopio, Teijo; Elomaa, Hanna; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Seppälä, Toni T.; Wirta, Erkki-Ville; Sihvo, Eero; Väyrynen, Juha P.; Yannopoulos, Fredrik; Helminen, Olli (Elsevier, 2023)Objective To evaluate the prognostic value of tumor budding and tumor-stroma ratio (TSR) in resected pulmonary metastases of colorectal carcinoma (CRC). Methods In total, 106 pulmonary metastasectomies were performed ... -
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Väyrynen, V.; Wirta, E; Seppälä, T.; Sihvo, E.; Mecklin, J-P.; Vasala, K.; Kellokumpu, I. (John Wiley & Sons, 2020)Background This population-based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods A retrospective population-based study was conducted on patients ... -
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