Physical function and lean body mass as predictors of bone loss after hip fracture : a prospective follow-up study
Suominen, T. H., Edgren, J., Salpakoski, A., Kallinen, M., Cervinka, T., Rantalainen, T., Törmäkangas, T., Heinonen, A., & Sipilä, S. (2020). Physical function and lean body mass as predictors of bone loss after hip fracture : a prospective follow-up study. BMC Musculoskeletal Disorders, 21, Article 367. https://doi.org/10.1186/s12891-020-03401-3
Published inBMC Musculoskeletal Disorders
DisciplineGerontologia ja kansanterveysBiomekaniikkaFysioterapiaGerontology and Public HealthBiomechanicsPhysiotherapy
© The Author(s). 2020
Background Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density and strength in older people recovering from a hip fracture. Methods A total of 81 over 60-year-old, community-dwelling men and women operated for a hip fracture participated in this 1-year prospective follow-up study. Distal tibia total volumetric bone mineral density (vBMDTOT, mg/cm3) and compressive strength index (BSI, g2/cm4) and mid-tibia cortical vBMD (vBMDCO, mg/cm3) and bending strength index (SSI, mm3) were assessed in both legs by peripheral quantitative computed tomography (pQCT) at baseline (on average 10 weeks after fracture) and at 12 months. At baseline, LBM was measured with a bioimpedance device and physical function with the Short Physical Performance Battery (SPPB) and perceived difficulty in walking outdoors. Robust multivariable linear regression models were used to estimate the associations of physical function and LBM with the change in bone parameters at 12-months. Results The mean change in distal tibia vBMDTOT and BSI in both legs ranged from − 0.9 to − 2.5%. The change in mid-tibia vBMDCO and SSI ranged from − 0.5 to − 2.1%. A lower SPPB score, difficulty in walking outdoors and lower LBM predicted greater decline in distal tibia vBMDTOT in both legs. A lower SPPB score and difficulty in walking outdoors were also associated with a greater decline in distal tibia BSI in both legs. At the midshaft site, a lower SPPB score and lower LBM were associated with greater decline in SSI on the fractured side. Conclusions Older hip fracture patients with low physical function and lower LBM may be at risk for greater decline in tibia bone properties during the first post-fracture year. Acknowledgement of the risk factors could assist in developing interventions and care to promote bone health and overall recovery. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Research costs of Academy Research Fellow, AoF; Research post as Academy Research Fellow, AoF; Postdoctoral Researcher, AoF
Additional information about fundingThe study was supported by grants from the Ministry of Education and Culture (SS, Grants Dnro 43/627/2007, 63/627/2008, 79/627/2009) and Kela (the Social Insurance Institution of Finland) (SS, Grant Dnro 24/26/2007). TT was funded by the Academy of Finland (grant no. 286536) and TR was an Academy Research Fellow during the preparation of this manuscript (Academy of Finland grant numbers 321336 and 328818). The funders had no role in the study design, data collection, analyses, or interpretation, or in writing the manuscript. ...
Showing items with similar title or keywords.
Physical disability in community-dwelling older people after hip fracture : randomized controlled trials with physical rehabilitation Edgren, Johanna (University of Jyväskylä, 2013)
Mortality Risk among Older People Who Did Versus Did Not Sustain a Fracture : Baseline Prefracture Strength and Gait Speed as Predictors in a 15-Year Follow-Up Koivunen, Kaisa; Sillanpää, Elina; von Bonsdorff, Mikaela; Sakari, Ritva; Törmäkangas, Timo; Rantanen, Taina (Oxford University Press; The Gerontological Society of America, 2020)BACKGROUND: Physiological reserve, as indicated by muscle strength and gait speed, may be especially determinant of survival in people who are exposed to a health stressor. We studied whether the association between ...
Body composition as a predictor of physical performance in older age : A ten-year follow-up of the Helsinki Birth Cohort Study Mikkola, Tuija M.; von Bonsdorff, Mikaela; Salonen, Minna K.; Simonen, Mika; Pohjolainen, Pertti; Osmond, Clive; Perälä, Mia-Maria; Rantanen, Taina; Kajantie, Eero; Eriksson, Johan G. (Elsevier Ireland Ltd., 2018)Background This study assessed how different measures of body composition predict physical performance ten years later among older adults. Methods The participants were 1076 men and women aged 57 to 70 years. Body ...
Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients Vehmanen, L.; Sievänen, H.; Kellokumpu-Lehtinen, P.; Nikander, R.; Huovinen, R.; Ruohola, J.; Penttinen, H. M.; Utriainen, M.; Tokola, K.; Blomqvist, C.; Saarto, T. (Springer, 2021)Summary A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost ...
Palmberg, Lotta; Portegijs, Erja; Rantanen, Taina; Aartolahti, Eeva; Viljanen, Anne; Hirvensalo, Mirja; Rantakokko, Merja (Human Kinetics, Inc., 2020)Background: Many older people report a willingness to increase outdoor physical activity (PA), but no opportunities for it, a situation termed as unmet PA need. The authors studied whether lower neighborhood mobility and ...