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dc.contributor.authorKairigo, Pius
dc.contributor.authorNgumba, Elijah
dc.contributor.authorSundberg, Lotta-Riina
dc.contributor.authorGachanja, Anthony
dc.contributor.authorTuhkanen, Tuula
dc.date.accessioned2020-05-25T11:45:42Z
dc.date.available2020-05-25T11:45:42Z
dc.date.issued2020
dc.identifier.citationKairigo, P., Ngumba, E., Sundberg, L.-R., Gachanja, A., & Tuhkanen, T. (2020). Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments. <i>Science of the Total Environment</i>, <i>720</i>, Article 137580. <a href="https://doi.org/10.1016/j.scitotenv.2020.137580" target="_blank">https://doi.org/10.1016/j.scitotenv.2020.137580</a>
dc.identifier.otherCONVID_34952163
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69194
dc.description.abstractActive pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to sensitive organisms. Here, we investigated the levels of selected antibiotics in four wastewater treatment plants and the receiving water bodies. The measured environmental concentrations were compared with the proposed compound-specific predicted no-effect concentration for resistance selection values. The concentration of doxycycline, amoxicillin, sulfamethoxazole, trimethoprim, ciprofloxacin and norfloxacin within the influents, effluents, surface waters and river sediments ranged between 0.2 and 49.3 μgL−1, 0.1 to 21.4 μgL−1; ˂ 0.1 and 56.6 μgL−1; and 1.8 and 47.4 μgkg−1, respectively. Compared to the effluent concentrations, the surface waters upstream and downstream one of the four studied treatment plants showed two to five times higher concentrations of ciprofloxacin, norfloxacin and sulfamethoxazole. The risk quotient for bacterial resistance selection in effluent and surface water ranged between ˂0.1 and 53, indicating a medium to high risk of antibiotic resistance developing within the study areas. Therefore, risk mitigation and prevention strategies are a matter of priority in the affected areas.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesScience of the Total Environment
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherantibiotics
dc.subject.otherwastewater
dc.subject.otherantimicrobial resistance
dc.subject.otherantibiotic resistance evolution
dc.subject.otherrisk assessment
dc.titleOccurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202005253447
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineYmpäristötiedefi
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineNanoscience Centeren
dc.contributor.oppiaineEnvironmental Scienceen
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0048-9697
dc.relation.volume720
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 Elsevier
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314939
dc.subject.ysojätevesikuormitus
dc.subject.ysojätevesi
dc.subject.ysopitoisuus
dc.subject.ysoantibioottiresistenssi
dc.subject.ysoantibiootit
dc.subject.ysovesien saastuminen
dc.subject.ysopintavesi
dc.subject.ysolääkeaineet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p12247
jyx.subject.urihttp://www.yso.fi/onto/yso/p5794
jyx.subject.urihttp://www.yso.fi/onto/yso/p1352
jyx.subject.urihttp://www.yso.fi/onto/yso/p29640
jyx.subject.urihttp://www.yso.fi/onto/yso/p10820
jyx.subject.urihttp://www.yso.fi/onto/yso/p7659
jyx.subject.urihttp://www.yso.fi/onto/yso/p11704
jyx.subject.urihttp://www.yso.fi/onto/yso/p1707
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.scitotenv.2020.137580
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis work was financially supported by the University of Jyväskylä doctoral program in the Department Biological and Environmental Science, the Academy of Finland (grant #314939) and by Jane and Aatos Erkko Foundation.


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