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dc.contributor.authorSaarinen, Timo
dc.contributor.authorKujala, Jan
dc.contributor.authorLaaksonen, Hannu
dc.contributor.authorJalava, Antti
dc.contributor.authorSalmelin, Riitta
dc.date.accessioned2020-04-07T07:15:28Z
dc.date.available2020-04-07T07:15:28Z
dc.date.issued2020
dc.identifier.citationSaarinen, T., Kujala, J., Laaksonen, H., Jalava, A., & Salmelin, R. (2020). Task-Modulated Corticocortical Synchrony in the Cognitive-Motor Network Supporting Handwriting. <i>Cerebral Cortex</i>, <i>30</i>(3), 1871-1886. <a href="https://doi.org/10.1093/cercor/bhz210" target="_blank">https://doi.org/10.1093/cercor/bhz210</a>
dc.identifier.otherCONVID_33477890
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68475
dc.description.abstractBoth motor and cognitive aspects of behavior depend on dynamic, accurately timed neural processes in large-scale brain networks. Here, we studied synchronous interplay between cortical regions during production of cognitive-motor sequences in humans. Specifically, variants of handwriting that differed in motor variability, linguistic content, and memorization of movement cues were contrasted to unveil functional sensitivity of corticocortical connections. Data-driven magnetoencephalography mapping (n = 10) uncovered modulation of mostly left-hemispheric corticocortical interactions, as quantified by relative changes in phase synchronization. At low frequencies (~2-13 Hz), enhanced frontoparietal synchrony was related to regular handwriting, whereas premotor cortical regions synchronized for simple loop production and temporo-occipital areas for a writing task substituting normal script with loop patterns. At the beta-to-gamma band (~13-45 Hz), enhanced synchrony was observed for regular handwriting in the central and frontoparietal regions, including connections between the sensorimotor and supplementary motor cortices and between the parietal and dorsal premotor/precentral cortices. Interpreted within a modular framework, these modulations of synchrony mainly highlighted interactions of the putative pericentral subsystem of hand coordination and the frontoparietal subsystem mediating working memory operations. As part of cortical dynamics, interregional phase synchrony varies depending on task demands in production of cognitive-motor sequences.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofseriesCerebral Cortex
dc.rightsCC BY-NC 4.0
dc.subject.otherDICS
dc.subject.otherMEG
dc.subject.otherfunctional connectivity
dc.subject.otherlanguage production
dc.subject.othermovement sequence
dc.titleTask-Modulated Corticocortical Synchrony in the Cognitive-Motor Network Supporting Handwriting
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202004072690
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1871-1886
dc.relation.issn1047-3211
dc.relation.numberinseries3
dc.relation.volume30
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.subject.ysomotoriikka
dc.subject.ysokirjoittaminen
dc.subject.ysoMEG
dc.subject.ysoaivokuori
dc.subject.ysokognitiiviset prosessit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p496
jyx.subject.urihttp://www.yso.fi/onto/yso/p2512
jyx.subject.urihttp://www.yso.fi/onto/yso/p3329
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p5283
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1093/cercor/bhz210
jyx.fundinginformationThis work was supported by the Academy of Finland (grant number 257576 to J.K.; 255349, 315553 to R.S); Finnish Cultural Foundation (grant number 00170944 to T.S.); Finnish Funding Agency for Technology and Innovation (SalWe Strategic Center for Science, Technology and Innovation in Health and Well-being; grant number 1104/10); and Sigrid Jusélius Foundation (no assigned grant number).


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CC BY-NC 4.0
Except where otherwise noted, this item's license is described as CC BY-NC 4.0