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dc.contributor.authorEsrafilian, A.
dc.contributor.authorStenroth, L.
dc.contributor.authorMononen, M. E.
dc.contributor.authorTanska, P.
dc.contributor.authorAvela, J.
dc.contributor.authorKorhonen, R. K.
dc.date.accessioned2020-02-24T11:49:22Z
dc.date.available2020-02-24T11:49:22Z
dc.date.issued2020
dc.identifier.citationEsrafilian, A., Stenroth, L., Mononen, M. E., Tanska, P., Avela, J., & Korhonen, R. K. (2020). EMG-Assisted Muscle Force Driven Finite Element Model of the Knee Joint with Fibril-Reinforced Poroelastic Cartilages and Menisci. <i>Scientific Reports</i>, <i>10</i>, Article 3026. <a href="https://doi.org/10.1038/s41598-020-59602-2" target="_blank">https://doi.org/10.1038/s41598-020-59602-2</a>
dc.identifier.otherCONVID_34697427
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67934
dc.description.abstractAbnormal mechanical loading is essential in the onset and progression of knee osteoarthritis. Combined musculoskeletal (MS) and finite element (FE) modeling is a typical method to estimate load distribution and tissue responses in the knee joint. However, earlier combined models mostly utilize static-optimization based MS models and muscle force driven FE models typically use elastic materials for soft tissues or analyze specific time points of gait. Therefore, here we develop an electromyography-assisted muscle force driven FE model with fibril-reinforced poro(visco)elastic cartilages and menisci to analyze knee joint loading during the stance phase of gait. Moreover, since ligament pre-strains are one of the important uncertainties in joint modeling, we conducted a sensitivity analysis on the pre-strains of anterior and posterior cruciate ligaments (ACL and PCL) as well as medial and lateral collateral ligaments (MCL and LCL). The model produced kinematics and kinetics consistent with previous experimental data. Joint contact forces and contact areas were highly sensitive to ACL and PCL pre-strains, while those changed less cartilage stresses, fibril strains, and fluid pressures. The presented workflow could be used in a wide range of applications related to the aetiology of cartilage degeneration, optimization of rehabilitation exercises, and simulation of knee surgeries.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.otherbiomedical engineering
dc.subject.othermechanical engineering
dc.titleEMG-Assisted Muscle Force Driven Finite Element Model of the Knee Joint with Fibril-Reinforced Poroelastic Cartilages and Menisci
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202002242156
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineBiomechanicsen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2020
dc.rights.accesslevelopenAccessfi
dc.subject.ysolihasvoima
dc.subject.ysotuki- ja liikuntaelimet
dc.subject.ysobiomekaniikka
dc.subject.ysopehmytkudokset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23362
jyx.subject.urihttp://www.yso.fi/onto/yso/p2785
jyx.subject.urihttp://www.yso.fi/onto/yso/p20292
jyx.subject.urihttp://www.yso.fi/onto/yso/p24162
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-020-59602-2
jyx.fundinginformationThis study was financially supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 713645, Academy of Finland (grants 286526, 324529) and Sigrid Juselius Foundation. CSC – IT Center for Science Ltd, Finland, is acknowledged for providing FE software.


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