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dc.contributor.authorRose, Richard J.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorAaltonen, Sari
dc.contributor.authorBarr, Peter B.
dc.contributor.authorBogl, Leonie H.
dc.contributor.authorByers, Holly A.
dc.contributor.authorHeikkilä, Kauko
dc.contributor.authorKorhonen, Tellervo
dc.contributor.authorLatvala, Antti
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorRanjit, Anu
dc.contributor.authorWhipp, Alyce M.
dc.contributor.authorPulkkinen, Lea
dc.contributor.authorDick, Danielle M.
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2020-01-07T06:52:00Z
dc.date.available2020-01-07T06:52:00Z
dc.date.issued2019
dc.identifier.citationRose, R. J., Salvatore, J. E., Aaltonen, S., Barr, P. B., Bogl, L. H., Byers, H. A., Heikkilä, K., Korhonen, T., Latvala, A., Palviainen, T., Ranjit, A., Whipp, A. M., Pulkkinen, L., Dick, D. M., & Kaprio, J. (2019). FinnTwin12 Cohort : An Updated Review. <i>Twin Research and Human Genetics</i>, <i>22</i>(5), 302-311. <a href="https://doi.org/10.1017/thg.2019.83" target="_blank">https://doi.org/10.1017/thg.2019.83</a>
dc.identifier.otherCONVID_33332105
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67091
dc.description.abstractThis review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofseriesTwin Research and Human Genetics
dc.rightsCC BY 4.0
dc.subject.otherlongitudinal twin-family study
dc.subject.otheralcohol
dc.subject.otherdiet
dc.subject.otherdiverse phenotypes
dc.subject.otherepigenetics
dc.subject.othergenetics
dc.subject.othermental health
dc.subject.othermetabolomics
dc.subject.otherphysical activity
dc.subject.othersmoking
dc.subject.othertwins
dc.subject.othertwo-stage design
dc.titleFinnTwin12 Cohort : An Updated Review
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202001071032
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange302-311
dc.relation.issn1832-4274
dc.relation.numberinseries5
dc.relation.volume22
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.subject.ysopitkittäistutkimus
dc.subject.ysotupakointi
dc.subject.ysoterveysriskit
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysomielenterveys
dc.subject.ysoperinnöllisyystiede
dc.subject.ysokohorttitutkimus
dc.subject.ysokaksostutkimus
dc.subject.ysoepigenetiikka
dc.subject.ysofenotyyppi
dc.subject.ysoruokavaliot
dc.subject.ysoalkoholinkäyttö
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p14610
jyx.subject.urihttp://www.yso.fi/onto/yso/p10017
jyx.subject.urihttp://www.yso.fi/onto/yso/p11098
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p1949
jyx.subject.urihttp://www.yso.fi/onto/yso/p5147
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
jyx.subject.urihttp://www.yso.fi/onto/yso/p18525
jyx.subject.urihttp://www.yso.fi/onto/yso/p24631
jyx.subject.urihttp://www.yso.fi/onto/yso/p13074
jyx.subject.urihttp://www.yso.fi/onto/yso/p3790
jyx.subject.urihttp://www.yso.fi/onto/yso/p8393
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1017/thg.2019.83
jyx.fundinginformationThis work was supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award numbers R01AA012502, R01AA015416, K02AA018755 and K01AA024152, and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, 264146 and 312073). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.


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