FinnTwin12 Cohort : An Updated Review
Rose, R. J., Salvatore, J. E., Aaltonen, S., Barr, P. B., Bogl, L. H., Byers, H. A., Heikkilä, K., Korhonen, T., Latvala, A., Palviainen, T., Ranjit, A., Whipp, A. M., Pulkkinen, L., Dick, D. M., & Kaprio, J. (2019). FinnTwin12 Cohort : An Updated Review. Twin Research and Human Genetics, 22(5), 302-311. https://doi.org/10.1017/thg.2019.83
Published inTwin Research and Human Genetics
© The Author(s) 2019
This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment. ...
PublisherCambridge University Press
longitudinal twin-family study alcohol diet diverse phenotypes epigenetics genetics mental health metabolomics physical activity smoking twins two-stage design pitkittäistutkimus tupakointi terveysriskit fyysinen aktiivisuus mielenterveys perinnöllisyystiede kohorttitutkimus kaksostutkimus epigenetiikka fenotyyppi ruokavaliot alkoholinkäyttö
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Additional information about fundingThis work was supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award numbers R01AA012502, R01AA015416, K02AA018755 and K01AA024152, and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278, 264146 and 312073). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. ...
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