Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen
von Bonsdorff, Mikaela B.; Haapanen, Markus J.; Törmäkangas, Timo; Pitkälä, Kaisu H.; Stenholm, Sari; Strandberg, Timo E. (2019). Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen. Journal of the American Geriatrics Society, 67 (12), 2490-2496. DOI: 10.1111/jgs.16150
Published inJournal of the American Geriatrics Society
© 2019 The American Geriatrics Society
OBJECTIVES. The associations between cardiovascular disease (CVD) risk and later physical functioning have been observed, but only a few studies with follow‐up into old age are available. We investigated the association between cardiovascular status in midlife and physical functioning trajectories in old age. DESIGN. Prospective cohort study. SETTING. Helsinki Businessmen Study. PARTICIPANTS. We studied white men born between 1919 and 1934 in the Helsinki Businessmen Study (HBS, initial n = 3490). MEASUREMENTS. Three CVD status groups were formed based on clinical measurements carried out in 1974: signs of CVD (diagnosed clinically or with changes in ECG, chronic disease present or used medication, n = 563); healthy and low CVD risk (n = 593) and high CVD risk (n = 1222). Of them, 1560 men had data on physical functioning from at least one of four data collection waves between 2000‐2010. Ten questions from the RAND‐36 (SF‐36) survey were used to construct physical functioning trajectories with latent class growth mixture models. Mortality was accounted for in competing risk models. RESULTS. A five‐class solution provided the optimal number of trajectories: “intact,” “high stable,” “high and declining,” “intermediate and declining,” and “consistently low” functioning. Compared with low CVD risk, high CVD risk in midlife decreased the risk of being classified into the intact (fully adjusted β = −3.98; standard error = 2.0; P = .046) relative to the consistently low physical functioning trajectory. Compared with low CVD risk, those with signs of CVD were less likely to follow the intact, high stable, or high and declining relative to the consistently low trajectory (all P < .018). CONCLUSION. Among businessmen, a more favorable CVD profile in midlife was associated with better development of physical functioning in old age. ...
PublisherWiley-Blackwell Publishing, Inc.
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- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Postdoctoral Researcher, AoF
Additional information about fundingThe Academy of Finland supported Mikaela B. von Bonsdorff with grant 257239 and EU H2020‐PHC‐2014‐DynaHealth grant 633595. The Academy of Finland supported Timo Törmäkangas with grant 286536. The Academy of Finland supported Sari Stenholm with grants 286294, 294154, and 319246.
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