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dc.contributor.authorWestberg, Anna P.
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorSalonen, Minna K.
dc.contributor.authorKajantie, Eero
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorEriksson, Johan G.
dc.date.accessioned2019-11-27T08:28:00Z
dc.date.available2019-11-27T08:28:00Z
dc.date.issued2019
dc.identifier.citationWestberg, A. P., Kautiainen, H., Salonen, M. K., Kajantie, E., von Bonsdorff, M., & Eriksson, J. G. (2019). The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood. <i>Diabetes Research and Clinical Practice</i>, <i>158</i>, Article 107926. <a href="https://doi.org/10.1016/j.diabres.2019.107926" target="_blank">https://doi.org/10.1016/j.diabres.2019.107926</a>
dc.identifier.otherCONVID_33600545
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/66538
dc.description.abstractAims We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied. Results There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p<0.001) and mean homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.049). According to the subjects’ own BMI, high maternal BMI was associated with lower 2-hour glucose concentrations only in non-obese men and with lower HOMA-IR only in obese men. Maternal BMI was not associated with glucose concentrations nor with HOMA-IR in women. In addition, maternal BMI was positively associated with a higher offspring lean body mass in men. Conclusions High maternal BMI was associated with lower 2-hour plasma glucose concentration, especially in non-obese men. Offspring lean body mass may be a mediating factor for the association.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesDiabetes Research and Clinical Practice
dc.rightsCC BY-NC-ND 4.0
dc.subject.othermaternal obesity
dc.subject.otheroffspring health
dc.subject.otherBMI
dc.subject.otherglucose metabolism
dc.subject.otherinsulin sensitivity
dc.titleThe impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201911275029
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn0168-8227
dc.relation.volume158
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoaineenvaihdunta
dc.subject.ysoaineenvaihduntahäiriöt
dc.subject.ysoinsuliiniresistenssi
dc.subject.ysoylipaino
dc.subject.ysolapset (perheenjäsenet)
dc.subject.ysolihavuus
dc.subject.ysoraskaus
dc.subject.ysoäidit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p6239
jyx.subject.urihttp://www.yso.fi/onto/yso/p22290
jyx.subject.urihttp://www.yso.fi/onto/yso/p826
jyx.subject.urihttp://www.yso.fi/onto/yso/p2357
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
jyx.subject.urihttp://www.yso.fi/onto/yso/p8749
jyx.subject.urihttp://www.yso.fi/onto/yso/p12279
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.diabres.2019.107926
jyx.fundinginformationHBCS was supported by Emil Aaltonen Foundation, Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Finnish Foundation for Pediatric Research, Juho Vainio Foundation, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) grant agreement no 278603 and EU H2020-PHC-2014-DynaHealth grant no. 633595. The Academy of Finland supported MBvB (grant no. 257239), EK (grant no. 127437, 129306, 130326, 134791 and 2639249) JGE (grant no. 129369, 129907, 135072, 129255 and 126775).


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