Life-space mobility in Parkinson’s disease : associations with motor and non-motor symptoms
Rantakokko, M., Iwarsson, S., Slaug, B., & Nilsson, M. H. (2019). Life-space mobility in Parkinson’s disease : associations with motor and non-motor symptoms. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 74(4), 507-512. https://doi.org/10.1093/gerona/gly074
© 2018 Oxford University Press
Background To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson’s disease (PD). Methods About 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III), and freezing of gait (item 3, FOG-Qsa). Non-motor symptoms included depressive symptoms (GDS-15), pain, fatigue (NHP-EN), and global cognition (MoCA). Life-space mobility was assessed with the life-space assessment (LSA). Calculations included composite score (range 0–120; higher indicating better life-space mobility), independent life-space (range 0–5), assisted life-space (range 0–5), and maximal life-space (range 0–5). Associations were analyzed with linear regression models, adjusted for age, sex, and PD severity (Hoehn and Yahr). Results Mean life-space mobility score was 72.3 (SD = 28.8). Almost all participants (90%) reached the highest life-space level (beyond town). Half of these reached this level independently, while one-third were unable to move outside their bedroom without assistive devices or personal help. When adjusted for confounders, depressive symptoms, pain, and perceived walking difficulties was negatively associated with life-space mobility. In the multivariable model, only perceived walking difficulties were associated with life-space mobility. Conclusions Our findings indicate that perceived walking difficulties should be targeted to maintain or improve life-space mobility in people with PD. Depressive symptoms and pain may also merit consideration. More research is needed to elucidate the role of environmental and personal factors for life-space mobility in PD. ...
PublisherOxford University Press
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Additional information about fundingThis work was supported by a personal grants to (M.R.) from the Academy of Finland (grant number 285747); and Ministry of Education and Culture. The Home and Health in Parkinson’s Disease Project was funded to (M.H.N. and S.I.) from the Strategic Research Area in neuroscience at Lund University (MultiPark); the Swedish Research Council; the Ribbingska Foundation in Lund; the Greta and Johan Kock Foundation; the Swedish Association of Persons with Neurological Disabilities (N.H.R.); Norrbacka-Eugenia Foundation; NEURO Sweden; and the Swedish Parkinson Foundation. This work was conducted in the context of the Centre for Ageing and Supportive Environments (CASE), financed by the Swedish Research Council for Health Care, Working Life, and Welfare (Forte). The financial sponsors played no role in the design, execution, analysis or interpretation of data, or writing of the study. ...
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