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dc.contributor.authorBell, Christina L.
dc.contributor.authorRantanen, Taina
dc.contributor.authorChen, Randi
dc.contributor.authorDavis, James
dc.contributor.authorPetrovitch, Helen
dc.contributor.authorRoss, G. Webster
dc.contributor.authorMasaki, Kamal
dc.date.accessioned2019-09-30T12:49:15Z
dc.date.available2019-09-30T12:49:15Z
dc.date.issued2014
dc.identifier.citationBell, C. L., Rantanen, T., Chen, R., Davis, J., Petrovitch, H., Ross, G. W., & Masaki, K. (2014). Prestroke Weight Loss Is Associated With Poststroke Mortality Among Men in the Honolulu-Asia Aging Study. <i>Archives of Physical Medicine and Rehabilitation</i>, <i>95</i>(3), 472-479. <a href="https://doi.org/10.1016/j.apmr.2013.09.019" target="_blank">https://doi.org/10.1016/j.apmr.2013.09.019</a>
dc.identifier.otherCONVID_23759024
dc.identifier.otherTUTKAID_62347
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65686
dc.description.abstractObjective To examine baseline prestroke weight loss and poststroke mortality among men. Design Longitudinal study of late-life prestroke body mass index (BMI), weight loss, and BMI change (midlife to late life) with up to 8-year incident stroke and mortality follow-up. Setting Community-based aging study data. Participants Japanese-American men (N=3581; age range, 71–93y) who were stroke free at baseline. Interventions Not applicable. Main Outcome Measure Poststroke mortality: 30 days poststroke, analyzed with stepwise multivariable logistic regression; and long-term poststroke (up to 8y), analyzed with stepwise multivariable Cox regression. Results Weight loss (4.5kg decrements) was associated with increased 30-day poststroke mortality (adjusted odds ratio=1.48; 95% confidence interval [CI], 1.14–1.92), long-term mortality after incident stroke (all types, n=225; adjusted hazards ratio (aHR)=1.25; 95% CI, 1.09–1.44), and long-term mortality after incident thromboembolic stroke (n=153; aHR=1.19; 95% CI, 1.01 to 1.40). Men with overweight/obese late-life BMI (≥25kg/m2, compared with healthy/underweight BMI) had increased long-term mortality after incident hemorrhagic stroke (n=54; aHR=2.27; 95% CI, 1.07–4.82). Neither desirable nor excessive BMI reductions (vs no change/increased BMI) were associated with poststroke mortality. In the overall sample (N=3581), nutrition factors associated with increased long-term mortality included the following: (1) weight loss (10lb decrements; aHR=1.15; 95% CI, 1.09–1.21), (2) underweight BMI (vs healthy BMI; aHR=1.76; 95% CI, 1.40–2.20), and (3) both desirable and excessive BMI reductions (vs no change or gain, separate model from weight loss and BMI; aHR range, 1.36–1.97; P<.001). Conclusions Although obesity is a risk factor for stroke incidence, prestroke weight loss was associated with increased poststroke (all types and thromboembolic) mortality. Overweight/obese late-life BMI was associated with increased posthemorrhagic stroke mortality. Desirable and excessive BMI reductions were not associated with poststroke mortality. Weight loss, underweight late-life BMI, and any BMI reduction were all associated with increased long-term mortality in the overall sample.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherW.B.Saunders Co.; American Congress of Rehabilitation Medicine
dc.relation.ispartofseriesArchives of Physical Medicine and Rehabilitation
dc.rightsIn Copyright
dc.subject.otheraged
dc.subject.othermortality
dc.subject.otherstroke
dc.titlePrestroke Weight Loss Is Associated With Poststroke Mortality Among Men in the Honolulu-Asia Aging Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909094064
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-09T12:15:18Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange472-479
dc.relation.issn0003-9993
dc.relation.numberinseries3
dc.relation.volume95
dc.type.versionacceptedVersion
dc.rights.copyright© 2014 by the American Congress of Rehabilitation Medicine
dc.rights.accesslevelopenAccessfi
dc.subject.ysopainoindeksi
dc.subject.ysomiehet
dc.subject.ysokuntoutus
dc.subject.ysolaihdutus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p21142
jyx.subject.urihttp://www.yso.fi/onto/yso/p8173
jyx.subject.urihttp://www.yso.fi/onto/yso/p3320
jyx.subject.urihttp://www.yso.fi/onto/yso/p825
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1016/j.apmr.2013.09.019


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