Prestroke Weight Loss Is Associated With Poststroke Mortality Among Men in the Honolulu-Asia Aging Study
Bell, C. L., Rantanen, T., Chen, R., Davis, J., Petrovitch, H., Ross, G. W., & Masaki, K. (2014). Prestroke Weight Loss Is Associated With Poststroke Mortality Among Men in the Honolulu-Asia Aging Study. Archives of Physical Medicine and Rehabilitation, 95(3), 472-479. https://doi.org/10.1016/j.apmr.2013.09.019
Published inArchives of Physical Medicine and Rehabilitation
© 2014 by the American Congress of Rehabilitation Medicine
Objective To examine baseline prestroke weight loss and poststroke mortality among men. Design Longitudinal study of late-life prestroke body mass index (BMI), weight loss, and BMI change (midlife to late life) with up to 8-year incident stroke and mortality follow-up. Setting Community-based aging study data. Participants Japanese-American men (N=3581; age range, 71–93y) who were stroke free at baseline. Interventions Not applicable. Main Outcome Measure Poststroke mortality: 30 days poststroke, analyzed with stepwise multivariable logistic regression; and long-term poststroke (up to 8y), analyzed with stepwise multivariable Cox regression. Results Weight loss (4.5kg decrements) was associated with increased 30-day poststroke mortality (adjusted odds ratio=1.48; 95% confidence interval [CI], 1.14–1.92), long-term mortality after incident stroke (all types, n=225; adjusted hazards ratio (aHR)=1.25; 95% CI, 1.09–1.44), and long-term mortality after incident thromboembolic stroke (n=153; aHR=1.19; 95% CI, 1.01 to 1.40). Men with overweight/obese late-life BMI (≥25kg/m2, compared with healthy/underweight BMI) had increased long-term mortality after incident hemorrhagic stroke (n=54; aHR=2.27; 95% CI, 1.07–4.82). Neither desirable nor excessive BMI reductions (vs no change/increased BMI) were associated with poststroke mortality. In the overall sample (N=3581), nutrition factors associated with increased long-term mortality included the following: (1) weight loss (10lb decrements; aHR=1.15; 95% CI, 1.09–1.21), (2) underweight BMI (vs healthy BMI; aHR=1.76; 95% CI, 1.40–2.20), and (3) both desirable and excessive BMI reductions (vs no change or gain, separate model from weight loss and BMI; aHR range, 1.36–1.97; P<.001). Conclusions Although obesity is a risk factor for stroke incidence, prestroke weight loss was associated with increased poststroke (all types and thromboembolic) mortality. Overweight/obese late-life BMI was associated with increased posthemorrhagic stroke mortality. Desirable and excessive BMI reductions were not associated with poststroke mortality. Weight loss, underweight late-life BMI, and any BMI reduction were all associated with increased long-term mortality in the overall sample. ...
PublisherW.B.Saunders Co.; American Congress of Rehabilitation Medicine
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Dzielska, Anna; Kelly, Colette; Ojala, Kristiina; Finne, Emily; Spinelli, Angela; Furstova, Jana; Fismen, Anne-Siri; Ercan, Oya; Tesler, Riki; Melkumova, Marina; Canale, Natale; Nardone, Paola; Gudelj Rakic, Jelena; Dalmasso, Paola (Elsevier, 2020)Purpose The purpose of this study was to analyze changes in the prevalence of weight reduction behaviors (WRBs) among European adolescents from 26 countries between 2001/2002 and 2017/2018. The impact of the perception ...
Explanations, motives and psychological flexibility associated in weight control among Finnish obese persons Sairanen, Essi (2010)Painonpudotukseen johtavien pysyvien käyttäytymismuutosten tekeminen on osoittautunut hyvin vaikeaksi, minkä vuoksi paino useimmiten nousee painonpudotuksen jälkeen. Tämän ilmiön paremmaksi ymmärtämiseksi tutkimuksemme ...
Normal weight obesity and physical fitness in Chinese university students: an overlooked association Zhang, Meizhen; Schumann, Moritz; Huang, Tao; Törmäkangas, Timo; Cheng, Sulin (BioMed Central, 2018)Background: The primary aim of this study was to examine the associations of normal weight obesity (NWO) with physical fitness in Chinese university students. As a secondary aim, we assessed whether possible differences ...
Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland Isiozor, Nzechukwu M.; Kunutsor, Setor K.; Voutilainen, Ari; Kurl, Sudhir; Kauhanen, Jussi; Laukkanen, Jari A. (Sage Publications, 2021)Background Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) ...
Mitochondrial bioenergetic pathways in blood leukocyte transcriptome decrease after intensive weight loss but are rescued following weight regain in female physique athletes Sarin, Heikki V.; Pirinen, Eija; Pietiläinen, Kirsi H.; Isola, Ville; Häkkinen, Keijo; Perola, Markus; Hulmi, Juha J. (Wiley, 2021)Prolonged periods of energy deficit leading to weight loss induce metabolic adaptations resulting in reduced energy expenditure, but the mechanisms for energy conservation are incompletely understood. We examined 42 healthy ...