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dc.contributor.authorArtigas, MS
dc.contributor.authorLoth, DW
dc.contributor.authorWain, LV
dc.contributor.authorGharib, SA
dc.contributor.authorObeidat, M
dc.contributor.authorTang, W
dc.contributor.authorZhai, G
dc.contributor.authorZhao, JH
dc.contributor.authorSmith, AV
dc.contributor.authorHuffman, JE
dc.contributor.authorAlbrecht, E
dc.contributor.authorJackson, CM
dc.contributor.authorEvans, DM
dc.contributor.authorCadby, G
dc.contributor.authorFornage, M
dc.contributor.authorManichaikul, A
dc.contributor.authorLopez, LM
dc.contributor.authorJohnson, T
dc.contributor.authorAldrich, MC
dc.contributor.authorRantanen, Taina
dc.date.accessioned2019-09-23T12:08:14Z
dc.date.available2019-09-23T12:08:14Z
dc.date.issued2011
dc.identifier.citationArtigas, M., Loth, D., Wain, L., Gharib, S., Obeidat, M., Tang, W., Zhai, G., Zhao, J., Smith, A., Huffman, J., Albrecht, E., Jackson, C., Evans, D., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L., Johnson, T., Aldrich, M., & Rantanen, T. (2011). Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function.. <i>Nature Genetics</i>, <i>43</i>(11), 1082-1090. <a href="https://doi.org/10.1038/ng.941" target="_blank">https://doi.org/10.1038/ng.941</a>
dc.identifier.otherCONVID_21008192
dc.identifier.otherTUTKAID_49065
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65618
dc.description.abstractPulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10−8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Group
dc.relation.ispartofseriesNature Genetics
dc.rightsIn Copyright
dc.subject.otherkeuhkotoiminta
dc.subject.othergenetiikka
dc.subject.otherlung function
dc.titleGenome-wide association and large scale follow-up identifies 16 new loci influencing lung function.
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909114117
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-11T12:15:37Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1082-1090
dc.relation.issn1061-4036
dc.relation.numberinseries11
dc.relation.volume43
dc.type.versionacceptedVersion
dc.rights.copyright© 2011 Springer Nature
dc.rights.accesslevelopenAccessfi
dc.subject.ysoperinnöllisyystiede
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5147
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1038/ng.941
dc.type.okmA1


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