A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol
Surakka, I., Whitfield, J., Perola, M., Visscher, P., Montgomery, G., Falchi, M., . . . Peltonen, L. (2012). A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Research and Human Genetics, 15 (6), 691-699. doi:10.1017/thg.2012.63
Published inTwin Research and Human Genetics
Widén, E |
Muilu, J |
DisciplineGerontologia ja kansanterveys
© The Authors 2012
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene–environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10−8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10−8). ...
PublisherCambridge University Press
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women : cross-sectional and longitudinal evidence Karvinen, Sira; Jergenson, Matthew J.; Hyvärinen, Matti; Aukee, Pauliina; Tammelin, Tuija; Sipilä, Sarianna; Kovanen, Vuokko; Kujala, Urho M.; Laakkonen, Eija K. (Frontiers Media, 2019)Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This ...
Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function. Artigas, MS; Loth, DW; Wain, LV; Gharib, SA; Obeidat, M; Tang, W; Zhai, G; Zhao, JH; Smith, AV; Huffman, JE; Albrecht, E; Jackson, CM; Evans, DM; Cadby, G; Fornage, M; Manichaikul, A; Lopez, LM; Johnson, T; Aldrich, MC; Rantanen, Taina (Nature Group, 2011)Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of ...
Associations of nutrition and body composition with cardiovascular disease risk factors in soldiers during a 6-month deployment Nykänen, Tarja Päivikki; Pihlainen, Kai; Kyröläinen, Heikki; Fogelholm, Mikael (Polish Association of Occupational Medicine, 2020)Objectives: This observational follow-up study investigated the associations of nutrition and body composition with cardiovascular disease (CVD) risk factors, including pro-inflammatory biomarkers, in soldiers during a ...
Eating behavior and cardiometabolic health : associations of eating habits with glucose and lipid metabolism in menopausal women Kansanen, Mari (2021)Background: Cardiovascular diseases (CVD) are the primary cause of death in women in developed countries. CVD risk increases with age and further accentuates after the onset of menopause in women. This finding suggests ...
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries NCD Risk Factor Collaboration (Oxford University Press, 2020)Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to ...