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dc.contributor.authorFolarin, Amos
dc.contributor.authorKonerding, Moritz
dc.contributor.authorTimonen, Jussi
dc.contributor.authorNagl, Sylvia
dc.contributor.authorPedley, Barbara
dc.date.accessioned2019-09-23T11:34:16Z
dc.date.available2019-09-23T11:34:16Z
dc.date.issued2010
dc.identifier.citationFolarin, A., Konerding, M., Timonen, J., Nagl, S., & Pedley, B. (2010). Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography. <i>Microvascular Res.</i>, <i>80</i>, 89-98. <a href="https://doi.org/10.1016/j.mvr.2010.03.007" target="_blank">https://doi.org/10.1016/j.mvr.2010.03.007</a>
dc.identifier.otherCONVID_20225121
dc.identifier.otherTUTKAID_44471
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65612
dc.description.abstractObjective In order to perform effective translational research for cancer therapy, we need to employ pre-clinical models which reflect the clinical situation. The purpose of this study was to quantitatively compare the vascular architecture of human colorectal cancer and experimental tumour models to determine the suitability of animal models for vascular studies and antivascular therapy. Methods In this study we investigated the three-dimensional properties of colonic tumour vasculature in both human clinical tissues (normal mucosa control [n = 20], carcinoma [n = 20] and adenoma [n = 6]) and murine colorectal xenografts (LS147T [n = 6] and SW1222 [n = 6]). Scanning Electron Microscope Stereoimaging (SEM) and X-ray Micro-Computed Tomography (Micro-CT) methods were employed for 3D analyses of the vascular corrosion casts from these tissues. Results Morphological measurements showed that there were significant differences in the underlying morphology in the different tissues. Of the studied xenografts, LS147T is more consistently similar to the vascular architecture of the human carcinoma than SW1222. The only reversal of this is for the inter-vessel distance. Conclusion While SEM stereoimaging provided better surface detailed resolution of the corrosion casts, it was complimented by the fully 3D micro-CT method. Comparison made between the xenografts and clinical tumours showed that the LS147T xenografts shared many similarities with the clinical tumour vasculature. This study provides insight into how to select the most suitable pre-clinical models for translational studies of clinical cancer therapy.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofseriesMicrovascular Res.
dc.rightsIn Copyright
dc.subject.otherverisuoniston mikrorakenne
dc.subject.otherkorroosiovalu
dc.subject.othermikrotomografia
dc.subject.otherangiogenesis
dc.subject.othertortuositeetti
dc.subject.othermicrovascular architecture
dc.subject.othercorrosion casting
dc.subject.othermicro-computed tomography
dc.subject.otherstereoimaging
dc.subject.othertortuosity
dc.titleThree-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909114119
dc.contributor.laitosFysiikan laitosfi
dc.contributor.laitosDepartment of Physicsen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-11T12:15:46Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange89-98
dc.relation.issn0026-2862
dc.relation.volume80
dc.type.versionacceptedVersion
dc.rights.copyright© 2010 Elsevier Inc
dc.rights.accesslevelopenAccessfi
dc.subject.ysostereokuvaus
dc.subject.ysoangiogeneesi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p17128
jyx.subject.urihttp://www.yso.fi/onto/yso/p22997
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1016/j.mvr.2010.03.007
dc.type.okmA1


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