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dc.contributor.authorPetersen, Inge
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorRantanen, Taina
dc.contributor.authorKremen, William S.
dc.contributor.authorJohnson, Wendy
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorChristiansen, Lene
dc.contributor.authorFranz, Carol E.
dc.contributor.authorMcGue, Matt
dc.contributor.authorChristensen, Kaare
dc.contributor.authorHamdi, Nayla R.
dc.contributor.authorKrueger, Robert F.
dc.contributor.authorReynolds, Chandra
dc.date.accessioned2019-09-18T10:31:41Z
dc.date.available2019-09-18T10:31:41Z
dc.date.issued2016
dc.identifier.citationPetersen, I., Pedersen, N. L., Rantanen, T., Kremen, W. S., Johnson, W., Panizzon, M. S., Christiansen, L., Franz, C. E., McGue, M., Christensen, K., Hamdi, N. R., Krueger, R. F., & Reynolds, C. (2016). G×E Interaction Influences Trajectories of Hand Grip Strength. <i>Behavior Genetics</i>, <i>46</i>(1), 20-30. <a href="https://doi.org/10.1007/s10519-015-9736-4" target="_blank">https://doi.org/10.1007/s10519-015-9736-4</a>
dc.identifier.otherCONVID_24903060
dc.identifier.otherTUTKAID_67222
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65550
dc.description.abstractAge-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34–99 (N = 10,681). Fisher’s test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectories.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer US; Behavior Genetics Association
dc.relation.ispartofseriesBehavior Genetics
dc.rightsIn Copyright
dc.subject.otherAPOE
dc.subject.otherGene-environment interaction
dc.subject.otherGrip strength
dc.titleG×E Interaction Influences Trajectories of Hand Grip Strength
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909184203
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-18T09:15:59Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange20-30
dc.relation.issn0001-8244
dc.relation.numberinseries1
dc.relation.volume46
dc.type.versionacceptedVersion
dc.rights.copyright© Springer Science+Business Media New York 2015
dc.rights.accesslevelopenAccessfi
dc.subject.ysokaksoset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p9845
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1007/s10519-015-9736-4


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