dc.contributor.author | Surakka, Ida | |
dc.contributor.author | Whitfield, JB | |
dc.contributor.author | Perola, M | |
dc.contributor.author | Visscher, PM | |
dc.contributor.author | Montgomery, GW | |
dc.contributor.author | Falchi, M | |
dc.contributor.author | Willemsen, G | |
dc.contributor.author | Geus, EJC de | |
dc.contributor.author | Magnusson, PKE | |
dc.contributor.author | Christensen, K | |
dc.contributor.author | Sorense, TIA | |
dc.contributor.author | Pietiläinen, KH | |
dc.contributor.author | Rantanen, Taina | |
dc.contributor.author | Silander, K | |
dc.contributor.author | Widén, E | |
dc.contributor.author | Muilu, J | |
dc.contributor.author | Rahman, I | |
dc.contributor.author | Liljedahl, U | |
dc.contributor.author | Syvänen, A-C | |
dc.contributor.author | Palotie, A | |
dc.contributor.author | Kaprio, J | |
dc.contributor.author | Kyvik, KO | |
dc.contributor.author | Pedersen, NL | |
dc.contributor.author | Boomsma, DI | |
dc.contributor.author | Spector, T | |
dc.contributor.author | Martin, NG | |
dc.contributor.author | Ripatti, S | |
dc.contributor.author | Peltonen, L | |
dc.date.accessioned | 2019-09-18T10:17:43Z | |
dc.date.available | 2019-09-18T10:17:43Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Surakka, I., Whitfield, J., Perola, M., Visscher, P., Montgomery, G., Falchi, M., Willemsen, G., Geus, E. D., Magnusson, P., Christensen, K., Sorense, T., Pietiläinen, K., Rantanen, T., Silander, K., Widén, E., Muilu, J., Rahman, I., Liljedahl, U., Syvänen, A.-C., . . . Peltonen, L. (2012). A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. <i>Twin Research and Human Genetics</i>, <i>15</i>(6), 691-699. <a href="https://doi.org/10.1017/thg.2012.63" target="_blank">https://doi.org/10.1017/thg.2012.63</a> | |
dc.identifier.other | CONVID_22178098 | |
dc.identifier.other | TUTKAID_54615 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/65549 | |
dc.description.abstract | Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene–environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98 × 10−8). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03 × 10−8). | |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Cambridge University Press | |
dc.relation.ispartofseries | Twin Research and Human Genetics | |
dc.relation.uri | http://journals.cambridge.org | |
dc.rights | In Copyright | |
dc.subject.other | genetiikka | |
dc.title | A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201909184204 | |
dc.contributor.laitos | Terveystieteiden laitos | fi |
dc.contributor.laitos | Department of Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2019-09-18T09:16:02Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 691-699 | |
dc.relation.issn | 1832-4274 | |
dc.relation.numberinseries | 6 | |
dc.relation.volume | 15 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Authors 2012 | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | kolesteroli | |
dc.subject.yso | perinnöllisyystiede | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p10609 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5147 | |
dc.rights.url | http://rightsstatements.org/page/InC/1.0/?language=en | |
dc.relation.doi | 10.1017/thg.2012.63 | |
dc.type.okm | A1 | |