Ion mobility-mass spectrometry of supramolecular complexes and assemblies
Kalenius, E., Groessl, M., & Rissanen, K. (2019). Ion mobility-mass spectrometry of supramolecular complexes and assemblies. Nature Reviews Chemistry, 3(1), 4-14. https://doi.org/10.1038/s41570-018-0062-2
Published in
Nature Reviews ChemistryDate
2019Copyright
© Macmillan Publishers Limited, part of
Springer Nature, 2019.
Despite their structural and functional differences, synthetic supramolecular assemblies share many similarities with biological assemblies, especially enzymes. The assemblies can be on the same length scale, and their structures and guest binding are typically governed by non-covalent interactions. Thus, only relatively weak interactions define the shape of a synthetic supramolecule or the secondary and tertiary structure of a protein, such that the resulting dynamism makes structure elucidation challenging. For biomolecules such as peptides, proteins, glycans and lipids this has often been tackled using ion mobility–mass spectrometry (IM-MS), whereby analyte ions are separated according to their gas-phase mobility and their mass-to-charge ratio. IM-MS is an established method in omics, separation sciences and small-molecule structural chemistry, but has only recently grown in popularity for the study of synthetic supramolecular assemblies in the gas phase. This Review describes IM-MS techniques and how they can help us understand the structures of molecular self-assemblies, host–guest complexes and metallosupramolecular complexes.
...
Publisher
Nature Publishing GroupISSN Search the Publication Forum
2397-3358Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/28766364
Metadata
Show full item recordCollections
Related funder(s)
Research Council of FinlandFunding program(s)
Research costs of Academy Research Fellow, AoFAdditional information about funding
The authors thank the Academy of Finland (project numbers 284562 and 312514) and the University of Jyväskylä for financial support.License
Related items
Showing items with similar title or keywords.
-
Supramolecular Assembly of Metal Complexes by (Aryl)I⋯dz2[PtII] Halogen Bond
Katlenok, Eugenе A.; Haukka, Matti; Levin, Oleg V.; Frontera, Antonio; Kukushkin, Vadim Yurievich (Wiley-VCH Verlag, 2020)The theoretical data for the half‐lantern complexes [Pt(C^N)(μ‐S^N)] 2 ( 1 – 3 ; С^N is cyclometalated 2‐Ph‐benzothiazole; S^N is 2‐SH‐pyridine 1 , 2‐SH‐benzoxazole 2 , 2‐SH‐tetrafluorobenzothiazole 3 ) indicate that the ... -
Binding Profiles of Self-Assembled Supramolecular Cages from ESI-MS Based Methodology
Bravin, Carlo; Badetti, Elena; Puttreddy, Rakesh; Pan, Fangfang; Rissanen, Kari; Licini, Giulia; Zonta, Cristiano (Wiley-VCH., 2018)Confined molecular environments have peculiar characteristics that make their properties unique in the field of biological and chemical sciences. In recent years, advances in supramolecular capsule and cage synthesis have ... -
Subcomponent self‐assembly of a cyclic tetranuclear Fe(II) helicate in a highly diastereoselective self‐sorting manner
Anhäuser, Jana; Puttreddy, Rakesh; Glanz, Lukas; Schneider, Andreas; Engeser, Marianne; Rissanen, Kari; Lützen, Arne (Wiley-VCH Verlag, 2019)An enantiomerically pure diamine based on the 4,15‐difunctionalized [2.2]paracyclophane scaffold and 2‐formylpyridine self‐assemble into an optically pure cyclic metallosupramolecular Fe₄L₆ helicate upon mixing with iron(II) ... -
Bringing a Molecular Plus One : Synergistic Binding Creates Guest-Mediated Three-Component Complexes
Taimoory, S. Maryamdokht; Twum, Kwaku; Dashti, Mohadeseh and Pan, FangFang; Lahtinen, Manu; Rissanen, Kari; Puttreddy, Rakesh; Trant, John F.; Beyeh, Ngong Kodiah (American Chemical Society, 2020)C-Ethyl-2-Methylresorcinarene (A), pyridine (B), and a set of ten carboxylic acids (Cn) associate to form A·B·Cn ternary assemblies with 1:1:1 stoichiometry, representing a useful class of ternary systems where the guest ... -
Iodine(I) and Silver(I) Complexes of Benzoimidazole and Pyridylcarbazole Derivatives
Rissanen, Kari; Taipale, Essi; Truong, Khai-Nghi; Siepmann, Marcel (Wiley, 2021)The synthesis of iodine(I) complexes with either benzoimidazole or carbazole-derived sp 2 N -containing Lewis bases is described, as well as their corresponding silver(I) complexes. The addition of elemental iodine to the ...