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dc.contributor.authorKalenius, Elina
dc.contributor.authorGroessl, Michael
dc.contributor.authorRissanen, Kari
dc.date.accessioned2019-05-27T08:53:35Z
dc.date.available2019-06-04T21:35:28Z
dc.date.issued2019
dc.identifier.citationKalenius, E., Groessl, M., & Rissanen, K. (2019). Ion mobility-mass spectrometry of supramolecular complexes and assemblies. <i>Nature Reviews Chemistry</i>, <i>3</i>(1), 4-14. <a href="https://doi.org/10.1038/s41570-018-0062-2" target="_blank">https://doi.org/10.1038/s41570-018-0062-2</a>
dc.identifier.otherCONVID_28766364
dc.identifier.otherTUTKAID_79778
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64202
dc.description.abstractDespite their structural and functional differences, synthetic supramolecular assemblies share many similarities with biological assemblies, especially enzymes. The assemblies can be on the same length scale, and their structures and guest binding are typically governed by non-covalent interactions. Thus, only relatively weak interactions define the shape of a synthetic supramolecule or the secondary and tertiary structure of a protein, such that the resulting dynamism makes structure elucidation challenging. For biomolecules such as peptides, proteins, glycans and lipids this has often been tackled using ion mobility–mass spectrometry (IM-MS), whereby analyte ions are separated according to their gas-phase mobility and their mass-to-charge ratio. IM-MS is an established method in omics, separation sciences and small-molecule structural chemistry, but has only recently grown in popularity for the study of synthetic supramolecular assemblies in the gas phase. This Review describes IM-MS techniques and how they can help us understand the structures of molecular self-assemblies, host–guest complexes and metallosupramolecular complexes.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Reviews Chemistry
dc.rightsIn Copyright
dc.subject.othermassaspektrometriafi
dc.subject.othersupramolekulaarinen kemiafi
dc.subject.othermass spectrometryfi
dc.subject.othersupramolecular chemistryfi
dc.titleIon mobility-mass spectrometry of supramolecular complexes and assemblies
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201905242778
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-05-24T06:15:22Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4-14
dc.relation.issn2397-3358
dc.relation.numberinseries1
dc.relation.volume3
dc.type.versionacceptedVersion
dc.rights.copyright© Macmillan Publishers Limited, part of Springer Nature, 2019.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber284562
dc.relation.grantnumber312514
dc.subject.ysomassaspektrometria
dc.subject.ysosupramolekulaarinen kemia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p10755
jyx.subject.urihttp://www.yso.fi/onto/yso/p37759
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1038/s41570-018-0062-2
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThe authors thank the Academy of Finland (project numbers 284562 and 312514) and the University of Jyväskylä for financial support.


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