Näytä suppeat kuvailutiedot

dc.contributor.authorBezuch, Natalia Ewa
dc.contributor.authorBradburn, Steven
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorPääsuke, Mati
dc.contributor.authorGapeyeva, Helena
dc.contributor.authorMaier, Andrea B.
dc.contributor.authorHogrel, Jean-Yves
dc.contributor.authorBarnouin, Yoann
dc.contributor.authorButler-Browne, Gillian
dc.contributor.authorNarici, Marco
dc.contributor.authorMcPhee, Jamie
dc.contributor.authorMurgatroyd, Chris
dc.date.accessioned2019-05-08T08:53:07Z
dc.date.available2020-02-02T22:35:21Z
dc.date.issued2019
dc.identifier.citationBezuch, N. E., Bradburn, S., Sipilä, S., Pääsuke, M., Gapeyeva, H., Maier, A. B., Hogrel, J.-Y., Barnouin, Y., Butler-Browne, G., Narici, M., McPhee, J., & Murgatroyd, C. (2019). Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults. <i>Meta Gene</i>, <i>19</i>, 51-55. <a href="https://doi.org/10.1016/j.mgene.2018.10.007" target="_blank">https://doi.org/10.1016/j.mgene.2018.10.007</a>
dc.identifier.otherCONVID_28696183
dc.identifier.otherTUTKAID_79364
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63824
dc.description.abstractWith increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels have been associated with the pathogenesis of dementia. The rs1800796 polymorphism in the promoter region of IL-6 gene was previously shown to influence IL-6 expression and therefore we hypothesised this gene polymorphism would be associated with IL-6 plasma levels and cognitive performance of older adults. The present study investigated the association of the rs1800796 polymorphism on plasma IL-6 levels and cognition in healthy older adults (n = 207, 74.6 ± 3.4 years, 51% female) that participated in a Pan-European project (MyoAge). The participants were assessed for working memory capacity, executive functioning, episodic memory and global cognition using the Cambridge Neuropsychological Test Automated Battery CANTAB. Fasting plasma IL-6 levels were measured by ELISA and genotyping was performed using the KASP assay. Results showed that the rs1800796 polymorphism was in Hardy-Weinberg equilibrium (P = .16) with the minor allele (C) showing a frequency of 6.3%. There were no differences in plasma IL-6 concentrations between the GG-homozygotes and C-allele carriers (P = .22). The C-allele carriers performed worse on a measure of executive functioning (P = .035) and had lower global cognitive scores (P = .045), compared to GG-homozygotes. These differences remained significant after accounting for age, sex and prior cognitive abilities (P < .05 for both). There were no differences in measures of memory (episodic and working) between the genotypes group. These findings suggest that the rs1800796 variant may be detrimental for executive functioning, but not memory, in healthy older adults.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesMeta Gene
dc.rightsCC BY-NC-ND 4.0
dc.subject.othercognitive aging
dc.subject.otheraging
dc.subject.otherinterleukin 6
dc.subject.otherrs1800796
dc.titleAssociation of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201905072430
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-05-07T09:15:41Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange51-55
dc.relation.issn2214-5400
dc.relation.numberinseries0
dc.relation.volume19
dc.type.versionacceptedVersion
dc.rights.copyright© 2018 Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyminen
dc.subject.ysokognitio
dc.subject.ysodementia
dc.subject.ysogeneettiset tekijät
dc.subject.ysosytokiinit
dc.subject.ysotulehdus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p642
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p21661
jyx.subject.urihttp://www.yso.fi/onto/yso/p22729
jyx.subject.urihttp://www.yso.fi/onto/yso/p1049
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.mgene.2018.10.007
dc.type.okmA1


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