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dc.contributor.authorMikkola, Tuija
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorOsmond, C.
dc.contributor.authorSalonen, M. K.
dc.contributor.authorKajantie, E.
dc.contributor.authorCooper, C.
dc.contributor.authorVälimäki, M. J.
dc.contributor.authorEriksson, J. G.
dc.date.accessioned2019-04-18T11:40:30Z
dc.date.available2019-04-18T11:40:30Z
dc.date.issued2017
dc.identifier.citationMikkola, T., von Bonsdorff, M., Osmond, C., Salonen, M. K., Kajantie, E., Cooper, C., Välimäki, M. J., & Eriksson, J. G. (2017). Childhood growth predicts higher bone mass and greater bone area in early old age : findings among a subgroup of women from the Helsinki Birth Cohort Study. <i>Osteoporosis International</i>, <i>28</i>(9), 2717-2722. <a href="https://doi.org/10.1007/s00198-017-4048-6" target="_blank">https://doi.org/10.1007/s00198-017-4048-6</a>
dc.identifier.otherCONVID_26972890
dc.identifier.otherTUTKAID_73615
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63567
dc.description.abstractSummary We examined the associations between childhood growth and bone properties among women at early old age. Early growth in height predicted greater bone area and higher bone mineral mass. However, information on growth did not improve prediction of bone properties beyond that predicted by body size at early old age. Introduction We examined the associations between body size at birth and childhood growth with bone area, bone mineral content (BMC), and areal bone mineral density (aBMD) in early old age. Methods A subgroup of women (n = 178, mean 60.4 years) from the Helsinki Birth Cohort Study, born 1934–1944, participated in dual-energy X-ray absorptiometry (DXA) measurements of the lumbar spine and hip. Height and weight at 0, 2, 7, and 11 years, obtained from health care records, were reconstructed into conditional variables representing growth velocity independent of earlier growth. Weight was adjusted for corresponding height. Linear regression models were adjusted for multiple confounders. Results Birth length and growth in height before 7 years of age were positively associated with femoral neck area (p < 0.05) and growth in height at all age periods studied with spine bone area (p < 0.01). Growth in height before the age of 7 years was associated with BMC in the femoral neck (p < 0.01) and birth length and growth in height before the age of 7 years were associated with BMC in the spine (p < 0.05). After entering adult height into the models, nearly all associations disappeared. Weight gain during childhood was not associated with bone area or BMC, and aBMD was not associated with early growth. Conclusions Optimal growth in height in girls is important for obtaining larger skeleton and consequently higher bone mass. However, when predicting bone mineral mass among elderly women, information on early growth does not improve prediction beyond that predicted by current height and weight.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer UK, European Foundation for Osteoporosis
dc.relation.ispartofseriesOsteoporosis International
dc.rightsIn Copyright
dc.subject.otherDXA
dc.titleChildhood growth predicts higher bone mass and greater bone area in early old age : findings among a subgroup of women from the Helsinki Birth Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201904162197
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-04-16T12:15:18Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2717-2722
dc.relation.issn0937-941X
dc.relation.numberinseries9
dc.relation.volume28
dc.type.versionacceptedVersion
dc.rights.copyright© International Osteoporosis Foundation and National Osteoporosis Foundation 2017
dc.rights.accesslevelopenAccessfi
dc.subject.ysonaiset
dc.subject.ysoikääntyminen
dc.subject.ysokohorttitutkimus
dc.subject.ysokasvu
dc.subject.ysoosteoporoosi
dc.subject.ysoluusto
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p16991
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
jyx.subject.urihttp://www.yso.fi/onto/yso/p5789
jyx.subject.urihttp://www.yso.fi/onto/yso/p10781
jyx.subject.urihttp://www.yso.fi/onto/yso/p7233
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1007/s00198-017-4048-6


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