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dc.contributor.authorLou, Yixue
dc.contributor.authorLei, Yi
dc.contributor.authorMei, Ying
dc.contributor.authorLeppänen, Paavo H.T.
dc.contributor.authorLi, Hong
dc.date.accessioned2019-04-12T10:33:29Z
dc.date.available2019-04-12T10:33:29Z
dc.date.issued2019fi
dc.identifier.citationLou, Y., Lei, Y., Mei, Y., Leppänen, P. H. T., & Li, H. (2019). Review of abnormal self-knowledge in major depressive disorder. <em>Frontiers in Psychiatry</em>, 10, 130. <a href="https://doi.org/10.3389/fpsyt.2019.00130">doi:10.3389/fpsyt.2019.00130</a>fi
dc.identifier.otherTUTKAID_81051
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63477
dc.description.abstractBackground: Major depressive disorder (MDD) is an affective disorder that is harmful to both physical and mental health. Abnormal self-knowledge, which refers to abnormal judgments about oneself, is a core symptom of depression. However, little research has summarized how and why patients with MDD differ from healthy individuals in terms of self-knowledge. Objective: To gain a better understanding of MDD, we reviewed previous studies that focused on the behavioral and neurological changes of self-knowledge in this illness. Main Findings: On the behavioral level, depressed individuals exhibited negative self-knowledge in an explicit way, while more heterogeneous patterns were reported in implicit results. On the neurological level, depressed individuals, as compared with non-depressed controls, showed abnormal self-referential processing in both early perception and higher cognitive processing phases during the Self-Referential Encoding Task. Furthermore, fMRI studies have reported aberrant activity in the medial prefrontal cortex area for negative self-related items in depression. These results revealed several behavioral features and brain mechanisms underlying abnormal self-knowledge in depression. Future Studies: The neural mechanism of implicit self-knowledge in MDD remains unclear. Future research should examine the importance of others' attitudes on the self-concept of individuals with MDD, and whether abnormal self-views may be modified through cognitive or pharmacological approaches. In addition, differences in abnormal self-knowledge due to genetic variation between depressed and non-depressed populations remain unconfirmed. Importantly, it remains unknown whether abnormal self-knowledge could be used as a specific marker to distinguish healthy individuals from those with MDD. Conclusion: This review extends our understanding of the relationship between self-knowledge and depression by indicating several abnormalities among individuals with MDD and those who are at risk for this illness.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Psychiatry
dc.rightsCC BY 4.0
dc.subject.othermasennusfi
dc.subject.otheritsetuntemusfi
dc.subject.otherkäyttäytymishäiriötfi
dc.subject.otherneurologiafi
dc.subject.othermajor depressive disorderfi
dc.subject.otherself-knowledgefi
dc.subject.otherabnormalityfi
dc.subject.otherbehavioral abnormalityfi
dc.subject.otherneurological abnormalityfi
dc.titleReview of abnormal self-knowledge in major depressive disorderfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201903292006
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-03-29T07:15:27Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-0640
dc.relation.numberinseries0
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 Lou, Lei, Mei, Leppänen and Li.
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fpsyt.2019.00130


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