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dc.contributor.authorSarin, H. V.
dc.contributor.authorLee, J. H.
dc.contributor.authorJauhiainen, M.
dc.contributor.authorJoensuu, A.
dc.contributor.authorBorodulin, K.
dc.contributor.authorMännistö, S.
dc.contributor.authorJin, Z.
dc.contributor.authorTerwilliger, J. D.
dc.contributor.authorIsola, V.
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorHäkkinen, Keijo
dc.contributor.authorKristiansson, K.
dc.contributor.authorHulmi, Juha
dc.contributor.authorPerola, M.
dc.date.accessioned2019-03-15T08:47:19Z
dc.date.available2019-03-15T08:47:19Z
dc.date.issued2019fi
dc.identifier.citationSarin, H. V., Lee, J. H., Jauhiainen, M., Joensuu, A., Borodulin, K., Männistö, S., . . . Perola, M. (2019). Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals. <em>Scientific Reports</em>, 9, 3450. <a href="https://doi.org/10.1038/s41598-019-40107-6">doi:10.1038/s41598-019-40107-6</a>fi
dc.identifier.otherTUTKAID_80938
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63141
dc.description.abstractThe accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and white blood cell transcriptomic markers in healthy, normal-weight individuals. The current study examined 42 healthy, young (age: 27.5 ± 4.0 years), normal-weight (body mass index, BMI: 23.4 ± 1.7 kg/m2) female athletes, of which 25 belong to the weight loss and regain group (diet group), and 17 to the control group. Participants were evaluated, and fasting blood samples were drawn at three time points: at baseline (PRE); at the end of the weight loss period (MID: 21.1 ± 3.1 weeks after PRE); and at the end of the weight regain period (POST: 18.4 ± 2.9 weeks after MID). Following the weight loss period, the diet group experienced a ~73% reduction (~0.69 kg) in visceral fat mass (false discovery rate, FDR < 2.0 × 10−16), accompanied by anti-atherogenic effects on transcriptomic markers, decreased low-grade inflammation (e.g., as α1–acid glycoprotein (FDR = 3.08 × 10−13) and hs-CRP (FDR = 2.44 × 10−3)), and an increase in functionally important anti-atherogenic high-density lipoprotein -associated metabolites (FDR < 0.05). This occurred even though these values were already at favorable levels in these participants, who follow a fitness-lifestyle compared to age- and BMI-matched females from the general population (n = 58). Following the weight regain period, most of the observed beneficial changes in visceral fat mass, and metabolomic and transcriptomic profiles dissipated. Overall, the beneficial anti-atherogenic effects of weight loss can be observed even in previously healthy, normal-weight individuals.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.otherkehonkoostumusfi
dc.subject.othertulehdusfi
dc.subject.otheraineenvaihduntafi
dc.subject.othermarkkeritfi
dc.subject.otherbody compositionfi
dc.subject.otherinflammationfi
dc.subject.othermetabolismfi
dc.subject.othermarkersfi
dc.titleSubstantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individualsfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201903121834
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologia
dc.contributor.oppiaineValmennus- ja testausoppi
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-03-12T16:15:08Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-40107-6


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