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dc.contributor.authorSarin, H. V.
dc.contributor.authorLee, J. H.
dc.contributor.authorJauhiainen, M.
dc.contributor.authorJoensuu, A.
dc.contributor.authorBorodulin, K.
dc.contributor.authorMännistö, S.
dc.contributor.authorJin, Z.
dc.contributor.authorTerwilliger, J. D.
dc.contributor.authorIsola, Ville
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorHäkkinen, Keijo
dc.contributor.authorKristiansson, K.
dc.contributor.authorHulmi, Juha
dc.contributor.authorPerola, M.
dc.date.accessioned2019-03-15T08:47:19Z
dc.date.available2019-03-15T08:47:19Z
dc.date.issued2019
dc.identifier.citationSarin, H. V., Lee, J. H., Jauhiainen, M., Joensuu, A., Borodulin, K., Männistö, S., Jin, Z., Terwilliger, J. D., Isola, V., Ahtiainen, J., Häkkinen, K., Kristiansson, K., Hulmi, J., & Perola, M. (2019). Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals. <i>Scientific Reports</i>, <i>9</i>, Article 3450. <a href="https://doi.org/10.1038/s41598-019-40107-6" target="_blank">https://doi.org/10.1038/s41598-019-40107-6</a>
dc.identifier.otherCONVID_28967228
dc.identifier.otherTUTKAID_80938
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63141
dc.description.abstractThe accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and white blood cell transcriptomic markers in healthy, normal-weight individuals. The current study examined 42 healthy, young (age: 27.5 ± 4.0 years), normal-weight (body mass index, BMI: 23.4 ± 1.7 kg/m2) female athletes, of which 25 belong to the weight loss and regain group (diet group), and 17 to the control group. Participants were evaluated, and fasting blood samples were drawn at three time points: at baseline (PRE); at the end of the weight loss period (MID: 21.1 ± 3.1 weeks after PRE); and at the end of the weight regain period (POST: 18.4 ± 2.9 weeks after MID). Following the weight loss period, the diet group experienced a ~73% reduction (~0.69 kg) in visceral fat mass (false discovery rate, FDR < 2.0 × 10−16), accompanied by anti-atherogenic effects on transcriptomic markers, decreased low-grade inflammation (e.g., as α1–acid glycoprotein (FDR = 3.08 × 10−13) and hs-CRP (FDR = 2.44 × 10−3)), and an increase in functionally important anti-atherogenic high-density lipoprotein -associated metabolites (FDR < 0.05). This occurred even though these values were already at favorable levels in these participants, who follow a fitness-lifestyle compared to age- and BMI-matched females from the general population (n = 58). Following the weight regain period, most of the observed beneficial changes in visceral fat mass, and metabolomic and transcriptomic profiles dissipated. Overall, the beneficial anti-atherogenic effects of weight loss can be observed even in previously healthy, normal-weight individuals.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.otherkehonkoostumusfi
dc.subject.othertulehdusfi
dc.subject.otheraineenvaihduntafi
dc.subject.othermarkkeritfi
dc.subject.otherbody compositionfi
dc.subject.otherinflammationfi
dc.subject.othermetabolismfi
dc.subject.othermarkersfi
dc.titleSubstantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201903121834
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineValmennus- ja testausoppifi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineScience of Sport Coaching and Fitness Testingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-03-12T16:15:08Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber275922
dc.subject.ysotulehdus
dc.subject.ysomarkkerit
dc.subject.ysokehonkoostumus
dc.subject.ysoaineenvaihdunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p1049
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p26989
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-40107-6
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis study was supported by grants from the Academy of Finland (grant numbers 269517 to M.P., 250207 to K.K., and 275922 to J.J.H.), the National Institute on Aging, NIH (R03 AG054186 to J.H.L., Z.J., J.D.T.), Jane and Aatos Erkko Foundation (M.J.), Finnish Foundation for Cardiovascular Research (M.J., A.J.), NovoNordisk Foundation (grant no. NNF16OC0020866 (M.P.)), Magnus Ehrnrooth Foundation (M.J.), Juho Vainio Foundation (H.V.S.), and Orion Pharma Foundation (H.V.S.). The authors thank the study participants, research assistants and laboratory personnel of the Physique and DILGOM/FINRISK cohorts. In addition, we also thank Jari Metso, M.Sc. and Päivi Laiho, Ph.D. for excellent laboratory assistance and Perttu Salo, Ph.D, Yiyi Ma and Vardarajan Badri for contributing their expertise on transciptomics. This study was also supported by grants: The EU FP7 under grant agreement HZ2020 633589 (Ageing with Elegans) and The Yrjö Jahnsson Foundation. DILGOM NMR metabolomics quantification was supported by the Yrjö Jahnsson Foundation.


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