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dc.contributor.authorGialluisi, Alessandro
dc.contributor.authorAndlauer, Till FM
dc.contributor.authorMirza-Schreiber, Nazanin
dc.contributor.authorMoll, Kristina
dc.contributor.authorBecker, Jessica
dc.contributor.authorHoffmann, Per
dc.contributor.authorLudwig, Kerstin U
dc.contributor.authorCzamara, Darina
dc.contributor.authorPourcain, Beate St
dc.contributor.authorBrandler, William
dc.contributor.authorHonbolygo, Ferenc
dc.contributor.authorToth, Denes
dc.contributor.authorCsepe, Valeria
dc.contributor.authorHuguet, Guillaume
dc.contributor.authorMorris, Andrew P
dc.contributor.authorHulslander, Jacqueline
dc.contributor.authorWillcutt, Erik G
dc.contributor.authorDeFries, John C
dc.contributor.authorOlson, Richard K
dc.contributor.authorSmith, Shelley D
dc.contributor.authorPennington, Bruce F
dc.contributor.authorVaessen, Anniek
dc.contributor.authorMaurer, Urs
dc.contributor.authorLyytinen, Heikki
dc.contributor.authorPeyrard-Janvid, Myriam
dc.contributor.authorLeppänen, Paavo H.T.
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorBonte, Milene
dc.contributor.authorStein, John F
dc.contributor.authorTalcott, Joel
dc.contributor.authorFauchereau, Fabien
dc.contributor.authorWilcke, Arndt
dc.contributor.authorFrancks, Clyde
dc.contributor.authorBourgeron, Thomas
dc.contributor.authorMonaco, Anthony P
dc.contributor.authorRamus, Franck
dc.contributor.authorLanderl, Karin
dc.contributor.authorKere, Juha
dc.contributor.authorScerri, Thomas S
dc.contributor.authorParacchini, Silvia
dc.contributor.authorFisher, Simon E
dc.contributor.authorSchumacher, Johannes
dc.contributor.authorNothen, Markus M
dc.contributor.authorMuller-Myhsok, Bertram
dc.contributor.authorSchulte-Korne, Gerd
dc.date.accessioned2019-02-22T10:23:13Z
dc.date.available2019-02-22T10:23:13Z
dc.date.issued2019fi
dc.identifier.citationGialluisi, A., Andlauer, T. F., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., . . . Schulte-Korne, G. (2019). Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia. <em>Translational Psychiatry</em>, 9, 77. <a href="https://doi.org/10.1038/s41398-019-0402-0">doi:10.1038/s41398-019-0402-0</a>fi
dc.identifier.otherTUTKAID_79717
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62933
dc.description.abstractDevelopmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p < 1 × 10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 × 10−9), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 × 10−8). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 × 10−8) and with all the cognitive traits tested (p = 3.07 × 10−8), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p ~ [10−5–10−7]) and negatively associated with ADHD PRS (p ~ [10−8−10−17]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesTranslational Psychiatry
dc.rightsCC BY 4.0
dc.subject.otherdysleksiafi
dc.subject.othergeenitfi
dc.subject.otherdyslexiafi
dc.subject.othergenesfi
dc.subject.otherpredictorsfi
dc.titleGenome-wide association scan identifies new variants associated with a cognitive predictor of dyslexiafi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201902121471
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-02-12T10:15:15Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2158-3188
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors 2019
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41398-019-0402-0


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