Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
Gialluisi, A., Andlauer, T. F., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., . . . Schulte-Korne, G. (2019). Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia. Translational Psychiatry, 9, 77. doi:10.1038/s41398-019-0402-0
Published inTranslational Psychiatry
© The Authors 2019
Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p < 1 × 10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA 924 host gene; rs17663182 p = 4.73 × 10−9), and a suggestive association on 8q12.3 within NKAIN3 (encoding a cation transporter; rs16928927, p = 2.25 × 10−8). rs17663182 (18q12.2) also showed genome-wide significant multivariate associations with RAN measures (p = 1.15 × 10−8) and with all the cognitive traits tested (p = 3.07 × 10−8), suggesting (relational) pleiotropic effects of this variant. A polygenic risk score (PRS) analysis revealed significant genetic overlaps of some of the DD-related traits with educational attainment (EDUyears) and ADHD. Reading and spelling abilities were positively associated with EDUyears (p ~ [10−5–10−7]) and negatively associated with ADHD PRS (p ~ [10−8−10−17]). This corroborates a long-standing hypothesis on the partly shared genetic etiology of DD and ADHD, at the genome-wide level. Our findings suggest new candidate DD susceptibility genes and provide new insights into the genetics of dyslexia and its comorbities. ...
PublisherNature Publishing Group
MetadataShow full item record
Showing items with similar title or keywords.
E, Repapi; I, Sayers; LV, Wain; RB, Burton; T, Johnson; M, Obeidat; JH, Zhao; A, Ramasamy; G, Zhai; V, Vitart; JE, Huffman; W, Igl; E, Albrecht; P, Deloukas; J, Henderson; J, Granell; WL, McArdle; AR, Rudnicka; Consortium, Wellcome Trust Case Control; I, Barroso; RJF, Loos; NJ, Wareham; L, Mustelin; Rantanen, Taina; I, Surakka; M, Imboden; HE, Wichmann; I, Grkovic; S, Jankovic; L, Zgaga; A, Hartikainen; L, Peltonen; U, Gyllensten; Å, Johansson; G, Zaboli; H, Campbell; SH, Wild; JF, Wilson; S, Gläser; G, Homuth; H, Völzke; M, Mangino; N, Soranzo; TD, Spector; O, Polašek; I, Rudan; AF, Wright; M, Heliövaara; S, Ripatti; A, Pouta; Å, Torinsson Naluai; A, Olin; K, Torén; MN, Cooper; AL, James; LJ, Palmer; AD, Hingorani; SG, Wannamethee; PH, Whincup; GD, Smith; S, Ebrahim; TM, McKeever; ID, Pavord; AK, MacLeod; AD, Morris; DJ, Porteous; C, Cooper; E, Dennison; S, Shaheen; S, Karrasch; E, Schnabel; H, Schulz; H, Grallert; N, Bouatia-Naji; J, Delplanque; P, Froguel; JD, Blakey; Team, The NSHD Respiratory Study; JR, Britton; RW, Morris; JW, Holloway; DA, Lawlor; J, Hui; F, Nyberg; M, Jarvelin; C, Jackson; M, Kähönen; J, Kaprio; NM, Probst-Hensch; B, Koch; C, Hayward; DE, Evans; P, Elliott; DP, Strachan; IP, Hall; MD, Tobin (Nature Publishing Group, 2010)Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) ...
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia Gialluisi, Alessandro; Andlauer, Till F. M.; Mirza-Schreiber, Nazanin; Moll, Kristina; Becker, Jessica; Hoffmann, Per; Ludwig, Kerstin U.; Czamara, Darina; Pourcain, Beate St; Honbolygó, Ferenc; Tóth, Dénes; Csépe, Valéria; Huguet, Guillaume; Chaix, Yves; Iannuzzi, Stephanie; Demonet, Jean-Francois; Morris, Andrew P.; Hulslander, Jacqueline; Willcutt, Erik G.; DeFries, John C.; Olson, Richard K.; Smith, Shelley D.; Pennington, Bruce F.; Vaessen, Anniek; Maurer, Urs; Lyytinen, Heikki; Peyrard-Janvid, Myriam; Leppänen, Paavo H. T.; Brandeis, Daniel; Bonte, Milene; Stein, John F.; Talcott, Joel B.; Fauchereau, Fabien; Wilcke, Arndt; Kirsten, Holger; Müller, Bent; Francks, Clyde; Bourgeron, Thomas; Monaco, Anthony P.; Ramus, Franck; Landerl, Karin; Kere, Juha; Scerri, Thomas S.; Paracchini, Silvia; Fisher, Simon E.; Schumacher, Johannes; Nöthen, Markus M.; Müller-Myhsok, Bertram; Schulte-Körne, Gerd (Nature Publishing Group, 2021)Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify ...
Loth, Daan W; Artigas, María Soler; Gharib, Sina A; Wain, Louise V; Franceschini, Nora; Koch, Beate; Pottinger, Tess D; Smith, Albert Vernon; Duan, Qing; Oldmeadow, Chris; Lee, Mi Kyeong; Strachan, David P; James, Alan L; Huffman, Jennifer E; Vitart, Veronique; Ramasamy, Adaikalavan; Wareham, Nicholas J; Kaprio, Jaakko; Wang, Xin-Qun; Trochet, Holly; Kähönen, Mika; Flexeder, Claudia; Albrecht, Eva; Lopez, Lorna M; Jong, Kim de; Rantanen, Taina (Nature Publishing Group, 2014)Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 ...
Shah, Rupal L.; Li, Qing; Zhao, Wanting; Tedja, Milly S.; Tideman, J. Willem L.; Khawaja, Anthony P.; Fan, Qiao; Yazar, Seyhan; Williams, Katie M.; Verhoeven, Virginie J.M.; Xie, Jing; Wang, Ya Xing; Hess, Moritz; Nickels, Stefan; Lackner, Karl J.; Pärssinen, Olavi; Wedenoja, Juho; Biino, Ginevra; Concas, Maria Pina; Uitterlinden, André; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Hysi, Pirro G.; Sim, Xueling; Tan, Nicholas; Tham, Yih-Chung; Sensaki, Sonoko; Hofman, Albert; Vingerling, Johannes R.; Jonas, Jost B.; Mitchell, Paul; Hammond, Christopher J.; Höhn, René; Baird, Paul N.; Wong, Tien-Yin; Cheng, Chinfsg-Yu; Teo, Yik Ying; Mackey, David A.; Williams, Cathy; Saw, Seang-Mei; Klaver, Caroline C.W.; Guggenheim, Jeremy A.; Bailey-Wilson, Joan E. (Molecular Vision, 2018)Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) ...
School-aged reading skills of children with family history of dyslexia : predictors, development and outcome Eklund, Kenneth (University of Jyväskylä, 2017)In this research I focused on reading skill development in school-age children with family history of dyslexia. I was interested in the effects of children’s cognitive skills (language, phonological awareness, rapid ...