Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
Shapiguzov, A., Vainonen, J. P., Hunter, K., Tossavainen, H., Tiwari, A., Järvi, S., Hellman, M., Aarabi, F., Alseekh, S., Wybouw, B., Kelen, K. V. D., Nikkanen, L., Krasensky-Wrzaczek, J., Sipari, N., Keinänen, M., Tyystjärvi, E., Rintamäki, E., De Rybel, B., Salojärvi, J., . . . Kangasjärvi, J. (2019). Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. eLife, 2019(8), Article e43284. https://doi.org/10.7554/elife.43284
Julkaistu sarjassa
eLifeTekijät
Päivämäärä
2019Oppiaine
Solu- ja molekyylibiologiaOrgaaninen kemiaNanoscience CenterCell and Molecular BiologyOrganic ChemistryNanoscience CenterTekijänoikeudet
© The Authors. 2019.
Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
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Julkaisija
eLife Sciences Publications Ltd.ISSN Hae Julkaisufoorumista
2050-084XAsiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28927621
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Suomen AkatemiaRahoitusohjelmat(t)
Akatemiahanke, SALisätietoja rahoituksesta
This work was supported by the University of Helsinki (JK); the Academy of Finland Centre of Excellence programs (2006–11; JK and 2014–19; JK, EMA) and Research Grant (Decision 250336; JK); Academy of Finland fellowships (Decisions 275632, 283139 and 312498; MW); Academy of Finland Research Grant (Decision 288235; PP); by The Research Foundation – Flanders (FWO; Odysseus II G0D0515N and Post-doc grant 12D1815N; BW and BDR); PlantaSYST project by the European Union’s Horizon 2020 research and innovation programme (SGA-CSA No 664621 and No. 739582 under FPA No. 664620; SA and ARF); Deutsche Forschungsgemeinschaft (DFG TRR 175 The Green Hub – Central Coordinator of Acclimation in Plants; FA and ARF); the Research Foundation – Flanders (Excellence of Science project no 30829584; FVB)![showless](/themes/JYX2//images/showless.png)
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