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dc.contributor.authorShapiguzov, Alexey
dc.contributor.authorVainonen, Julia P.
dc.contributor.authorHunter, Kerri
dc.contributor.authorTossavainen, Helena
dc.contributor.authorTiwari, Arjun
dc.contributor.authorJärvi, Sari
dc.contributor.authorHellman, Maarit
dc.contributor.authorAarabi, Fayezeh
dc.contributor.authorAlseekh, Saleh
dc.contributor.authorWybouw, Brecht
dc.contributor.authorKelen, Katrien Van Der
dc.contributor.authorNikkanen, Lauri
dc.contributor.authorKrasensky-Wrzaczek, Julia
dc.contributor.authorSipari, Nina
dc.contributor.authorKeinänen, Markku
dc.contributor.authorTyystjärvi, Esa
dc.contributor.authorRintamäki, Eevi
dc.contributor.authorDe Rybel, Bert
dc.contributor.authorSalojärvi, Jarkko
dc.contributor.authorvan Breusegem, Frank
dc.contributor.authorFernie, Alisdair R.
dc.contributor.authorBrosché, Mikael
dc.contributor.authorPermi, Perttu
dc.contributor.authorAro, Eva-Mari
dc.contributor.authorWrzaczek, Michael
dc.contributor.authorKangasjärvi, Jaakko
dc.date.accessioned2019-02-22T06:54:05Z
dc.date.available2019-02-22T06:54:05Z
dc.date.issued2019
dc.identifier.citationShapiguzov, A., Vainonen, J. P., Hunter, K., Tossavainen, H., Tiwari, A., Järvi, S., Hellman, M., Aarabi, F., Alseekh, S., Wybouw, B., Kelen, K. V. D., Nikkanen, L., Krasensky-Wrzaczek, J., Sipari, N., Keinänen, M., Tyystjärvi, E., Rintamäki, E., De Rybel, B., Salojärvi, J., . . . Kangasjärvi, J. (2019). Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. <i>eLife</i>, <i>2019</i>(8), Article e43284. <a href="https://doi.org/10.7554/elife.43284" target="_blank">https://doi.org/10.7554/elife.43284</a>
dc.identifier.otherCONVID_28927621
dc.identifier.otherTUTKAID_80699
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62928
dc.description.abstractReactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publishereLife Sciences Publications Ltd.
dc.relation.ispartofserieseLife
dc.rightsCC BY 4.0
dc.subject.otherarabidopsis RCD1
dc.subject.otherchloroplast
dc.subject.othermitochondrial functions
dc.subject.otherANAC transcription factors
dc.titleArabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201902211619
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineOrganic Chemistryen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-02-21T16:15:20Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2050-084X
dc.relation.numberinseries8
dc.relation.volume2019
dc.type.versionacceptedVersion
dc.rights.copyright© The Authors. 2019.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber288235
dc.subject.ysoproteiinit
dc.subject.ysokasvit
dc.subject.ysobiokemia
dc.subject.ysomitokondriot
dc.subject.ysoviherhiukkaset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p4332
jyx.subject.urihttp://www.yso.fi/onto/yso/p1755
jyx.subject.urihttp://www.yso.fi/onto/yso/p1375
jyx.subject.urihttp://www.yso.fi/onto/yso/p21158
jyx.subject.urihttp://www.yso.fi/onto/yso/p21157
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.7554/elife.43284
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis work was supported by the University of Helsinki (JK); the Academy of Finland Centre of Excellence programs (2006–11; JK and 2014–19; JK, EMA) and Research Grant (Decision 250336; JK); Academy of Finland fellowships (Decisions 275632, 283139 and 312498; MW); Academy of Finland Research Grant (Decision 288235; PP); by The Research Foundation – Flanders (FWO; Odysseus II G0D0515N and Post-doc grant 12D1815N; BW and BDR); PlantaSYST project by the European Union’s Horizon 2020 research and innovation programme (SGA-CSA No 664621 and No. 739582 under FPA No. 664620; SA and ARF); Deutsche Forschungsgemeinschaft (DFG TRR 175 The Green Hub – Central Coordinator of Acclimation in Plants; FA and ARF); the Research Foundation – Flanders (Excellence of Science project no 30829584; FVB)
dc.type.okmA1


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