Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

Fries, Martin; Mertens, Meike; Teske, Nico; Kipp, Markus; Beyer, Cordian; Willms, Thomas; Valkonen, Arto; Rissanen, Kari; Albrecht, Markus; Clarner, Tim

doi:10.1021/acsomega.8b02523

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Fries, M., Mertens, M., Teske, N., Kipp, M., Beyer, C., Willms, T., Valkonen, A., Rissanen, K., Albrecht, M., & Clarner, T. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. ACS Omega, 4(1), 1685-1689. https://doi.org/10.1021/acsomega.8b02523

Julkaistu sarjassa

ACS Omega

Tekijät

Fries, Martin |

Mertens, Meike |

Teske, Nico |

Kipp, Markus |

Beyer, Cordian |

Willms, Thomas |

Valkonen, Arto |

Rissanen, Kari |

Albrecht, Markus |

Clarner, Tim

Päivämäärä

2019

Oppiaine

Orgaaninen kemia Nanoscience Center Organic Chemistry Nanoscience Center

Tekijänoikeudet

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

Julkaisija

American Chemical Society

ISSN Hae Julkaisufoorumista

2470-1343

Rahoittaja(t)

Suomen Akatemia

Rahoitusohjelmat(t)

Akatemiatutkijan tutkimuskulut, SA

Lisätietoja rahoituksesta

This study was funded by the “Excellence Initiative of the German federal and state governments”, the Academy of Finland (A.V. grant no. 314343), and the University of Jyväskylä.

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