Towards Controlled Synthesis of Water-Soluble Gold Nanoclusters : Synthesis and Analysis
Sokolowska, K., Malola, S., Lahtinen, M., Saarnio, V., Permi, P., Koskinen, K., Jalasvuori, M., Häkkinen, H., Lehtovaara, L., & Lahtinen, T. (2019). Towards Controlled Synthesis of Water-Soluble Gold Nanoclusters : Synthesis and Analysis. The Journal of Physical Chemistry C, 123(4), 2602-2612. https://doi.org/10.1021/acs.jpcc.8b11056
Published inThe Journal of Physical Chemistry C
DisciplineSolu- ja molekyylibiologiaEpäorgaaninen ja analyyttinen kemiaFysikaalinen kemiaOrgaaninen kemiaNanoscience CenterCell and Molecular BiologyInorganic and Analytical ChemistryPhysical ChemistryOrganic ChemistryNanoscience Center
© 2019 American Chemical Society.
Water-soluble gold nanoclusters with well-defined molecular structures and stability possess particular biophysical properties making them excellent candidates for biological applications as well as for fundamental spectroscopic studies. The currently existing synthetic protocols for atomically monodisperse thiolate-protected gold nanoclusters (AuMPCs) have been widely expanded with organothiolates, yet the direct synthesis reports for water-soluble AuMPCs are still deficient. Here, we demonstrate a wet-chemistry pH-controlled synthesis of two large water-soluble nanoclusters utilizing p-mercaptobenzoic acid (pMBA), affording different sizes of plasmonic AuMPCs on the preparative scale (∼7 mg). AuMPCs are essentially homogenous in size and are stable in solution and the solid state. Number of characterization methods were used to gain detailed information about the size, symmetry, molecular composition, and structure of these systems, i.e., high-resolution transmission electron microscopy, powder X-ray diffraction, NMR, UV-vis, thermogravimetry, and polyacrylamide gel electrophoresis. On the basis of the conducted experimental analyses and computationally aided predictions it can be evidenced that both clusters exhibit twinned face-centered cubic symmetry with the molecular composition of Au210-230(pMBA)70-80 and Au426-442(pMBA)112-115, referred from now on as Au250 and Au500, respectively. For future reference, toxicity of both gold clusters in various concentrations on cultures of Gram-positive and Gram-negative bacteria was investigated. ...
PublisherAmerican Chemical Society
ISSN Search the Publication Forum1932-7447
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Research costs of Academy Research Fellow, AoF; Research post as Academy Professor, AoF; Academy Research Fellow, AoF; Research costs of Academy Professor, AoF
Additional information about fundingThis work was financially supported by the Academy of Finland via projects 269402, 273499, 303753 (L.L.), 252411, 297049, 292352 (H.H.), 294217 (H.H.), and Emil Aaltonen Foundation grant to M.J. Notes The authors declare no competing financial interest.
Showing items with similar title or keywords.
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies Fries, Martin; Mertens, Meike; Teske, Nico; Kipp, Markus; Beyer, Cordian; Willms, Thomas; Valkonen, Arto; Rissanen, Kari; Albrecht, Markus; Clarner, Tim (American Chemical Society, 2019)The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or ...
Water soluble organometallic small molecules as promising antibacterial agents : synthesis, physical–chemical properties and biological evaluation to tackle bacterial infections Bennour, Ines; Núria Ramos, M.; Nuez-Martínez, Miquel; Xavier, Jewel Ann Maria; Buades, Ana B.; Sillanpää, Reijo; Teixidor, Francesc; Choquesillo-Lazarte, Duane; Romero, Isabel; Martinez-Medina, Margarita; Viñas, Clara (Royal Society of Chemistry (RSC), 2022)The Na[3,3′-Fe(8-I-1,2-C2B9H10)2] and Na[2,2′-M(1,7-C2B9H11)] (M = Co3+, Fe3+) small molecules are synthesized and the X-ray structures of [(H3O)(H2O)5][2,2′-Co(1,7-C2B9H11)2] and [Cs(MeCN)][8,8′-I2-Fe(1,2 C2B9H10)2], both ...
Synthesis, characterization, and reactivity of heavier group 13 and 14 metallylenes and metalloid clusters : small molecule activation and more Vasko, Petra (University of Jyväskylä, 2015)
Synthesis, X-ray Structure, Conformational Analysis, and DFT Studies of a Giant s-Triazine bis-Schiff Base Almarhoon, Zainab M.; Al-Zaben, Maha I.; Ben Bacha, Abir; Haukka, Matti; El-Faham, Ayman; Soliman, Saied M. (MDPI AG, 2021)The current work involves the synthesis of 2,2′-(6-(piperidin-1-yl)-1,3,5-triazine-2,4-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol 4, characterization, and the DFT studies of the reported compound. The ...
Control of N-Heterocyclic Carbene Catalyzed Reactions of Enals: Asymmetric Synthesis of Oxindole-γ-Amino Acid Derivatives Chen, Xiang-Yu; Xiong, Jia-Wen; Liu, Qiang; Li, Sun; Sheng, He; von Essen, Carolina; Rissanen, Kari; Enders, Dieter (Wiley-VCH., 2018)A strategy to control the switch between a non‐cycloaddition reaction and a cycloaddition reaction of enals, using N‐heterocyclic carbene (NHC) catalyisis, has been developed. The new scalable protocol leads to γ‐amino‐acid ...