Towards Controlled Synthesis of Water-Soluble Gold Nanoclusters : Synthesis and Analysis
Sokolowska, K., Malola, S., Lahtinen, M., Saarnio, V., Permi, P., Koskinen, K., Jalasvuori, M., Häkkinen, H., Lehtovaara, L., & Lahtinen, T. (2019). Towards Controlled Synthesis of Water-Soluble Gold Nanoclusters : Synthesis and Analysis. The Journal of Physical Chemistry C, 123(4), 2602-2612. https://doi.org/10.1021/acs.jpcc.8b11056
Published inThe Journal of Physical Chemistry C
DisciplineSolu- ja molekyylibiologiaEpäorgaaninen ja analyyttinen kemiaFysikaalinen kemiaOrgaaninen kemiaNanoscience CenterCell and Molecular BiologyInorganic and Analytical ChemistryPhysical ChemistryOrganic ChemistryNanoscience Center
© 2019 American Chemical Society.
Water-soluble gold nanoclusters with well-defined molecular structures and stability possess particular biophysical properties making them excellent candidates for biological applications as well as for fundamental spectroscopic studies. The currently existing synthetic protocols for atomically monodisperse thiolate-protected gold nanoclusters (AuMPCs) have been widely expanded with organothiolates, yet the direct synthesis reports for water-soluble AuMPCs are still deficient. Here, we demonstrate a wet-chemistry pH-controlled synthesis of two large water-soluble nanoclusters utilizing p-mercaptobenzoic acid (pMBA), affording different sizes of plasmonic AuMPCs on the preparative scale (∼7 mg). AuMPCs are essentially homogenous in size and are stable in solution and the solid state. Number of characterization methods were used to gain detailed information about the size, symmetry, molecular composition, and structure of these systems, i.e., high-resolution transmission electron microscopy, powder X-ray diffraction, NMR, UV-vis, thermogravimetry, and polyacrylamide gel electrophoresis. On the basis of the conducted experimental analyses and computationally aided predictions it can be evidenced that both clusters exhibit twinned face-centered cubic symmetry with the molecular composition of Au210-230(pMBA)70-80 and Au426-442(pMBA)112-115, referred from now on as Au250 and Au500, respectively. For future reference, toxicity of both gold clusters in various concentrations on cultures of Gram-positive and Gram-negative bacteria was investigated. ...
PublisherAmerican Chemical Society
Publication in research information system
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Related funder(s)Academy of Finland
Funding program(s)Research costs of Academy Research Fellow, AoF; Research post as Academy Professor, AoF; Research post as Academy Research Fellow, AoF; Research costs of Academy Professor, AoF
Additional information about fundingThis work was financially supported by the Academy of Finland via projects 269402, 273499, 303753 (L.L.), 252411, 297049, 292352 (H.H.), 294217 (H.H.), and Emil Aaltonen Foundation grant to M.J. Notes The authors declare no competing financial interest.
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