Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
Fries, M., Mertens, M., Teske, N., Kipp, M., Beyer, C., Willms, T., Valkonen, A., Rissanen, K., Albrecht, M., & Clarner, T. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. ACS Omega, 4(1), 1685-1689. https://doi.org/10.1021/acsomega.8b02523
Julkaistu sarjassa
ACS OmegaTekijät
Päivämäärä
2019Tekijänoikeudet
© 2019 American Chemical Society.
The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.
Julkaisija
American Chemical SocietyISSN Hae Julkaisufoorumista
2470-1343Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28876658
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This study was funded by the “Excellence Initiative of the German federal and state governments”, the Academy of Finland (A.V. grant no. 314343), and the University of Jyväskylä.Lisenssi
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