Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training
Ahtiainen, J., Lensu, S., Ruotsalainen, I., Schumann, M., Ihalainen, J., Fachada, V., Mendias, C. L., Brook, M. S., Smith, K., Atherton, P. J., Koch, L. G., Britton, S. L., & Kainulainen, H. (2018). Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Experimental Physiology, 103(11), 1513-1523. https://doi.org/10.1113/EP087144
Published inExperimental Physiology
DisciplinePsykologiaLiikuntafysiologiaValmennus- ja testausoppiPsychologyExercise PhysiologyScience of Sport Coaching and Fitness Testing
© 2018 The Authors and The Physiological Society
The purpose of this study was to determine whether rats selectively bred for low and high response to aerobic exercise training co‐segregate for differences in muscle adaptations to ladder‐climbing resistance training. Five high‐responder (HRT) and five low‐responder (LRT) rats completed the resistance training, while six HRT and six LRT rats served as sedentary control animals. Before and after the 6 week intervention, body composition was determined by dual energy X‐ray absorptiometry. Before tissue harvesting, the right triceps surae muscles were loaded by electrical stimulation. Muscle fibre cross‐sectional areas, nuclei per cell, phosphorylation status of selected signalling proteins of mTOR and Smad pathways, and muscle protein, DNA and RNA concentrations were determined for the right gastrocnemius muscle. The daily protein synthesis rate was determined by the deuterium oxide method from the left quadriceps femoris muscle. Tissue weights of fore‐ and hindlimb muscles were measured. In response to resistance training, maximal carrying capacity was greater in HRT (∼3.3 times body mass) than LRT (∼2.5 times body mass), indicating greater improvements of strength in HRT. However, muscle hypertrophy that could be related to greater strength gains in HRT was not observed. Furthermore, noteworthy changes within the experimental groups or differences between groups were not observed in the present measures. The lack of hypertrophic muscular adaptations despite considerable increases in muscular strength suggest that adaptations to the present ladder‐climbing training in HRT and LRT rats were largely induced by neural adaptations. ...
PublisherWiley-Blackwell Publishing Ltd.
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Related funder(s)Academy of Finland
Funding program(s)Academy Programme, AoF
Additional information about fundingThis work was supported by the Academy of Finland (grant no. 274098 to H.K.) and META‐PREDICT within the European Union Seventh Framework Program (HEALTH‐F2‐2012‐277936 to H.K.). This work was also supported by the Medical Research Council (grant no. MR/K00414X/1) and Arthritis Research UK (grant no. 19891) as part of the MRC‐ARUK Centre for Musculoskeletal Ageing Research; the Physiological Society (awarded to P.J.A. and K.S.); the Dunhill Medical Trust (R264/1112 to K.S. and P.J.A.); and a Medical Research Council Confidence in Concept award (CIC12019 to P.J.A. and K.S.). The LRT‐HRT rat model system was supported by the Office of Research Infrastructure Programs/OD grant ROD012098A (to L.G.K. and S.L.B.) from the National Institutes of Health (USA). Contact L.G.K. (firstname.lastname@example.org) or S.L.B. (email@example.com) for information on the LRT and HRT rats; these rat models are maintained as an international collaborative resource at the University of Toledo, Toledo, OH, USA. ...
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