Formal synthesis of ent-Cephalotaxine using a one-pot Parham-aldol sequence
Siitonen, J., Yu, L., Danielsson, J., Gregorio, G. D., & Somfai, P. (2018). Formal synthesis of ent-Cephalotaxine using a one-pot Parham-aldol sequence. Journal of Organic Chemistry, 83(18), 11318-11322. https://doi.org/10.1021/acs.joc.8b01540
Published inJournal of Organic Chemistry
© American Chemical Society, 2018
A short formal synthesis of ent-Cephalotaxine is achieved. The approach features a new Lewis acid mediated [2,3]-Stevens rearrangement of N-allylated prolineamide to generate a key quaternary stereogenic center. Additionally, a one-pot Parham–aldol sequence was developed to rapidly assembly two of the four rings in the cephalotaxine core.
PublisherAmerican Chemical Society
Publication in research information system
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