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dc.contributor.authorWang, Jiarui
dc.contributor.authorTian, Jinhua
dc.contributor.authorHao, Renning
dc.contributor.authorTian, Lili
dc.contributor.authorLiu, Qiang
dc.date.accessioned2018-06-11T05:34:40Z
dc.date.available2018-06-11T05:34:40Z
dc.date.issued2018
dc.identifier.citationWang, J., Tian, J., Hao, R., Tian, L., & Liu, Q. (2018). Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory. <i>PeerJ</i>, <i>6</i>, e4906. <a href="https://doi.org/10.7717/peerj.4906" target="_blank">https://doi.org/10.7717/peerj.4906</a>
dc.identifier.otherCONVID_28070950
dc.identifier.otherTUTKAID_77734
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/58476
dc.description.abstractBackground Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined as executive control and storage process. Previous studies mainly focused on the overall effect of transcranial direct current stimulation (tDCS) on working memory. However, little has been known about the segregative effects of tDCS on the sub-processes within working memory. Method Transcranial direct current stimulation, as one of the non-invasive brain stimulation techniques, is being widely used to modulate the cortical activation of local brain areas. This study modified a spatial n-back experiment with anodal and cathodal tDCS exertion on the right dorsolateral prefrontal cortex (DLPFC), aiming to investigate the effects of tDCS on the two sub-processes of working memory: manipulation (updating) and maintenance. Meanwhile, considering the separability of tDCS effects, we further reconfirmed the causal relationship between the right DLPFC and the sub-processes of working memory with different tDCS conditions. Results The present study showed that cathodal tDCS on the right DLPFC selectively improved the performance of the modified 2-back task in the difficult condition, whereas anodal tDCS significantly reduced the performance of subjects and showed an speeding-up tendency of response time. More precisely, the results of discriminability index and criterion showed that only cathodal tDCS enhanced the performance of maintenance in the difficult condition. Neither of the two tDCS conditions affected the performance of manipulation (updating). Conclusion These findings provide evidence that cathodal tDCS of the right DLPFC selectively affects maintenance capacity. Besides, cathodal tDCS also serves as an interference suppressor to reduce the irrelevant interference, thereby indirectly improving the working memory capacity. Moreover, the right DLPFC is not the unique brain regions for working memory manipulation (updating).fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherPeerJ Inc.
dc.relation.ispartofseriesPeerJ
dc.rightsCC BY 4.0
dc.subject.othermuisti
dc.subject.othermemory
dc.titleTranscranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201805302892
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-05-30T09:15:14Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerangee4906
dc.relation.issn2167-8359
dc.relation.numberinseries0
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 Wang et al.
dc.rights.accesslevelopenAccessfi
dc.subject.ysotyömuisti
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13896
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.7717/peerj.4906
dc.type.okmA1


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